1332508-67-4Relevant articles and documents
Synthesis and biological evaluation of novel indolin-2-one derivatives as protein tyrosine phosphatase 1b inhibitors
Dai, Hou-Ling,Shen, Qiang,Zheng, Jian-Bin,Lib, Jing-Ya,Wen, Ren,Li, Jia
, p. 526 - 530 (2012/04/23)
3-Substituted indolin-2-one derivatives had been designed and synthesized as a novel class ofprotein tyrosine phosphatase 1B (PTP1B) inhibitors. These compounds had been evaluated for their inhibitory activities against PTP1B in vitro with IC50 values in a low micromolar range.Compound 36, the lowest, bore an IC50 value of 3.48 μM. Preliminary structure-activity relationship was summarized.