1332707-96-6

Basic information

• Product Name: C₁₆H₃₁N₃O
• CAS NO: 1332707-96-6
• Molecular Weight: 281.442
• Mol File: 1332707-96-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₃₁N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₃₁N₃O(1332707-96-6)
• EPA Substance Registry System: C₁₆H₃₁N₃O(1332707-96-6)

Safety Data

• Hazardous Substances Data: 1332707-96-6(Hazardous Substances Data)

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 1332707-95-5 C₂₁H₃₉N₃O₃ 
• 150008-24-5 tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate 

Downstream Products

• 1056674-53-3 1-(1-acetylpiperidin-4-yl)-3-(4-tert-butyl-cyclohexyl)urea 

Relevant articles and documents

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin resistance in pre-diabetic patients. In a mouse model of diet induced obesity, AR9281 attenuated the enhanced glucose excursion following an intraperitoneal glucose tolerance test. AR9281 also attenuated the increase in blood pressure in angiotensin-II-induced hypertension in rats. These effects were dose-dependent and well correlated with inhibition of the sEH activity in whole blood, consistent with a role of sEH in the observed pharmacology in rodents.