133295-89-3Relevant articles and documents
Iron(III)-catalyzed tandem sequential methanol oxidation/aldol coupling
Lecomte, Vincent,Bolm, Carsten
, p. 1666 - 1672 (2005)
Iron(III)-catalyzed methanol oxidations have been performed using hydrogen peroxide as oxidant. Formaldehyde is formed in situ and reacts subsequently with activated ketones to give α-hydroxymethyl carbonyl compounds in good yields. As side reactions iron
Diastereoselectivity control of the radical carboazidation of substituted methylenecyclohexanes
Cren, Sylvaine,Schar, Pascal,Renaud, Philippe,Schenk, Kurt
supporting information; experimental part, p. 2942 - 2946 (2009/09/06)
A systematic study of the diastereoselectivity of the radical carboazidation of methylenecyclohexane derivatives is presented. Several substitution patterns leading to a high level of stereocontrol have been identified. Axial attack is the preferred reaction pathway for cyclohexyl radicals, and excellent stereoselectivities can be obtained by introducing an axial substitutent at position 2. In this case, a second equatorial substituent at position 2 may be tolerated without a large detrimental effect on the diastereoselectivity. Finally, a high level of equatorial attack is observed with a very bulky substituent at position 2.
