133384-65-3Relevant articles and documents
Benzoxazolyl linked benzylidene based rhodanine and analogs as novel antidiabetic agents: synthesis, molecular docking, and in vitro studies
Singh, Varinder,Singh, Amanjot,Singh, Gagandeep,Verma, Raman K.,Mall, Rajiv
, p. 1905 - 1914 (2021/08/27)
Benzoxazolyl linked meta- and para-substituted new chemical entities (5a–5h) featuring thiazolidinedione, rhodanine, hydantoin, and thiohydantoin moieties were synthesized and characterized by 1H NMR, 13C NMR, FT-IR, and HRMS spectra
Synthesis and reactivity of 5-methylenehydantoins
Fraile, José M.,Lafuente, Gustavo,Mayoral, José A.,Pallarés, Antonio
experimental part, p. 8639 - 8647 (2011/11/30)
5-Methylenehydantoin, as well as the N-mono- and N,N-di-protected derivatives, can be obtained by different synthetic routes. These compounds can undergo a large variety of reactions, such as Diels-Alder, epoxidation, methanol addition and conjugate addition reactions of different types of nucleophiles, including carbon (cyanide), nitrogen (piperidine) and sulfur (thiols, thioacetate) nucleophiles. The reactivity with electrophilic reagents, such as m-CPBA or methanol in acidic medium, and the need for Lewis acids to promote the conjugate addition reactions indicate that hydantoin is a poor electron-withdrawing group.
Latent Inhibitors. Part 6. Inhibition of Dihydro-orotate Dehydrogenase by Substituted 5-Benzylhydantoins
Howie, Colin,Suckling, Colin J.,Wood, Hamish C. S.
, p. 3129 - 3135 (2007/10/02)
A series of substituted 5-benzyl-3-(1-carboxy-2-phenylethyl)hydantoins was prepared by condensation of aromatic aldehydes with the corresponding 5-unsubstituted hydantoin followed by reduction of the intermediate benzylidene derivative.The compounds were
