1334169-96-8

Basic information

• Product Name: Amino-PEG8-t-Boc-Hydrazide
• Synonyms: Amino-PEG8-t-Boc-Hydrazide;Amino-PEG8- Boc-Hydrazide;NH2-PEG8-HZ-Boc
• CAS NO: 1334169-96-8
• Molecular Formula: C24H49N3O11
• Molecular Weight: 555.65936
• Mol File: 1334169-96-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.116±0.06 g/cm3(Predicted)
• PKA: 8.99±0.43(Predicted)
• CAS DataBase Reference: Amino-PEG8-t-Boc-Hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Amino-PEG8-t-Boc-Hydrazide(1334169-96-8)
• EPA Substance Registry System: Amino-PEG8-t-Boc-Hydrazide(1334169-96-8)

Safety Data

• Hazardous Substances Data: 1334169-96-8(Hazardous Substances Data)

Usage

Description

Amino-PEG8-t-Boc-Hydrazide is a versatile crosslinker that features an amino group and a Boc-protected hydrazide. The presence of a hydrophilic PEG8 spacer enhances its solubility in aqueous environments, making it suitable for a range of applications. The amine group is reactive with various functional groups such as carboxylic acids, activated NHS esters, and carbonyls (including ketones and aldehydes). The Boc-protecting group can be removed under mild acidic conditions, revealing a reactive hydrazide group that can be coupled with a variety of carbonyl-containing compounds.

Uses

Used in Bioconjugation:
Amino-PEG8-t-Boc-Hydrazide is used as a bioconjugation agent for the attachment of biomolecules to other molecules or surfaces. The reason for its use is its reactivity with various functional groups and the ability to form stable linkages upon deprotection of the Boc group.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Amino-PEG8-t-Boc-Hydrazide is used as a component in drug delivery systems for the development of targeted therapies. Its role is to facilitate the attachment of drug molecules to carriers or other targeting moieties, improving the drug's solubility, stability, and targeted delivery.
Used in Materials Science:
Amino-PEG8-t-Boc-Hydrazide is utilized as a crosslinking agent in the synthesis of hydrogels, polymers, and other materials. The reason for its application is its ability to react with multiple types of functional groups and its hydrophilic nature, which can improve the properties of the resulting materials, such as their swelling behavior, mechanical properties, and biocompatibility.
Used in Diagnostics:
In the diagnostics field, Amino-PEG8-t-Boc-Hydrazide is employed as a component in the development of immunoassays and other diagnostic tools. Its use is due to its ability to form stable conjugates with detection molecules, enhancing the sensitivity and specificity of diagnostic assays.
Used in Chemical Synthesis:
Amino-PEG8-t-Boc-Hydrazide is used as an intermediate in the synthesis of various organic compounds, taking advantage of its reactivity with different functional groups and the hydrophilic PEG spacer for improved solubility during the reaction process.