1334172-76-7

Basic information

• Product Name: Biotin-PEG7-Amine
• Synonyms: Biotin-PEG7-Amine;Biotin-PEG7-NH2;Biotin-dPEG(R)7-NH2;N-(23-amino-3,6,9,12,15,18,21-heptaoxatricosyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide;Biotin-PEG8-amine
• CAS NO: 1334172-76-7
• Molecular Formula: C26H50N4O9S
• Molecular Weight: 594.7616
• Mol File: 1334172-76-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 785.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.151±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 13.90±0.40(Predicted)
• CAS DataBase Reference: Biotin-PEG7-Amine(CAS DataBase Reference)
• NIST Chemistry Reference: Biotin-PEG7-Amine(1334172-76-7)
• EPA Substance Registry System: Biotin-PEG7-Amine(1334172-76-7)

Safety Data

• Hazardous Substances Data: 1334172-76-7(Hazardous Substances Data)

Usage

Description

Biotin-PEG7-Amine is a biotin PEG reagent that is reactive with NHS ester or with carboxylic acid in the presence of EDC or HATU activator. It is a versatile molecule that combines the properties of biotin, a vitamin known for its role in cell growth and metabolism, with polyethylene glycol (PEG), a hydrophilic polymer that enhances solubility and stability. The amine functional group allows for further conjugation and modification, making Biotin-PEG7-Amine a valuable tool in various applications.

Uses

Used in Bioconjugation:
Biotin-PEG7-Amine is used as a bioconjugation agent for attaching biomolecules such as proteins, peptides, or antibodies to other molecules or surfaces. The biotin moiety provides specific binding to avidin or streptavidin, while the PEG spacer improves solubility and reduces immunogenicity or non-specific interactions.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Biotin-PEG7-Amine is used as a component in drug delivery systems to improve the pharmacokinetics and biodistribution of therapeutic agents. The PEGylation of drugs can enhance their solubility, stability, and circulation time in the body, while the biotin group can facilitate targeted delivery to specific cells or tissues.
Used in Diagnostic Assays:
Biotin-PEG7-Amine is used as a component in diagnostic assays, such as enzyme-linked immunosorbent assays (ELISA) or immunohistochemistry, to enhance the detection and quantification of specific biomolecules. The biotin-streptavidin interaction provides a highly sensitive and specific signal amplification mechanism.
Used in Biosensor Development:
In the field of biosensors, Biotin-PEG7-Amine is used as a component in the design and fabrication of sensors for detecting various analytes, such as small molecules, proteins, or nucleic acids. The biotin-PEG-amine structure allows for the immobilization of recognition elements on sensor surfaces, while the PEG spacer provides a stable and biocompatible environment for the sensor operation.
Used in Tissue Engineering:
In tissue engineering, Biotin-PEG7-Amine is used as a component in the design of scaffolds or hydrogels for promoting cell adhesion, growth, and differentiation. The biotin group can be used to immobilize cell-adhesive peptides or growth factors, while the PEG spacer provides a hydrophilic and biocompatible environment for cell culture.