13343-95-8Relevant articles and documents
Synthesis, molecular docking and antimicrobial activity of new fused pyrimidine and pyridine derivatives
Radwan, Mohamed A.A.,Alshubramy, Maha A.,Abdel-Motaal, Marwa,Hemdan, Bahaa A.,El-Kady, Dina S.
, (2020)
Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure of the new compounds was interpreted by spectral studies and ESI-MS analysis.
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation, and ulcerogenic liability of new 1,3,5-triarylpyrazoline derivatives possessing a methanesulfonyl pharmacophore
Abdellatif, Khaled R. A.,Fadaly, Wael A. A.,Azouz, Amany A.
, p. 1 - 7 (2016/10/11)
A new series of 1,3,5-triarylpyrazolines 13a–l was synthesized and all prepared compounds were evaluated for their in vitro COX-1/COX-2 inhibitory activity and in vivo anti-inflammatory activity. All test compounds were more selective for the COX-2 isozyme and showed good in vivo anti-inflammatory activity. Compound 13h was the most COX-2 selective compound (COX-2 selectivity index (SI)=10.23) and the most potent anti-inflammatory derivative (ED50-60.1μmol/kg) in comparison with celecoxib (COX-2 SI=9.29 and ED50=81.4μmol/kg). All screened compounds were less ulcerogenic (ulcer indexes (UI)=0.33–1.33) than aspirin (UI=2.33) and comparable to celecoxib (UI=0.33).
Atom-efficient, solvent-free, green synthesis of chalcones by grinding
Rateb, Nora M.,Zohdi, Hussein F.
experimental part, p. 2789 - 2794 (2009/12/06)
An improved Claisen-Schmidt condensation reaction of methyl ketones and aromatic aldehydes can be achieved by grinding at room temperature in the absence of solvents. This process is simple, efficient, economical, and environmentally benign compared to classical reactions.
