1334336-40-1

Basic information

• Product Name: C₃₈H₅₀O₃Si
• Synonyms: C₃₈H₅₀O₃Si
• CAS NO: 1334336-40-1
• Molecular Weight: 582.899
• Mol File: 1334336-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₈H₅₀O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₈H₅₀O₃Si(1334336-40-1)
• EPA Substance Registry System: C₃₈H₅₀O₃Si(1334336-40-1)

Safety Data

• Hazardous Substances Data: 1334336-40-1(Hazardous Substances Data)

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 1700-30-7 (3-(benzyloxy)phenyl)methanol 
• 1700-31-8 3-benzyloxybenzyl bromide 
• 57711-40-7 3-(O-tert-butyl(dimethyl)silyl)estrone 
• 1700-37-4 3-Benzyloxybenzaldehyde 

Downstream Products

• 1215115-63-1 (17β)-17-(3-benzyloxybenzyl)-estra-1(10),2,4-triene-3,17-diol 

Relevant articles and documents

Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase

Steroid sulfatase (STS) controls the levels of 3-hydroxysteroids available from circulating steroid sulfates in several normal and malignant tissues. This and the known involvement of active estrogens and androgens in diseases such as breast and prostate cancers thus make STS an interesting therapeutic target. Here we describe the chemical synthesis and characterization of an extended series of 17α-derivatives of estradiol (E2) using different strategies. A variant of the samarium-Barbier reaction with stoichiometric samarium metal and catalytic Kagan reagent formation was used for introducing low reactive benzyl substrates in position 17 of estrone (E1) whereas heterocyclic substrates were metalated and reacted with either the carbonyl or the 17-oxirane of E1. In vitro evaluation of the inhibitory potency of the new compounds against STS identified new inhibitors and allowed a more complete structure-activity relationship study of this family of 17α-derivatives of E2.