1334513-11-9Relevant articles and documents
Tricyclic nucleotide analogue as well as synthesis method and application thereof
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, (2022/03/27)
The invention belongs to the field of chemical synthesis, and particularly relates to tricyclic nucleotide analogues shown as formulas (I), (II), (III) and (IV) as well as a synthesis method and application thereof. The structural formulas of the tricyclic nucleotide analogues are shown in formulas (I), (II), (III) and (IV), wherein the compounds in the formulas (I), (II), (III) and (IV) are compounds containing a ternary aza fused ring skeleton. According to the synthesis, AcOH which is relatively friendly to the environment is used as a solvent, Ac2O is used as an additive, 1, 1, 3, 3-tetramethoxypropane is connected with imino groups on guanosine or 2 '-deoxyguanosine and cyclization is carried out, so that a series of tricyclic nucleotide analogues with novel structures are constructed. The experiment process is simple and convenient to operate, the yield is high, the chemical selectivity is good, a series of tricyclic nucleotide analogues with novel structures can be efficiently constructed, and a new method and thought are provided for synthesis of the compounds.