133627-46-0

Basic information

• Product Name: 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide
• Synonyms: 2-CHLORO-N-(2-CHLORO-4-METHYL-3-PYRIDYL)-3-PYRIDINE CARBOXAMIDE;2-chloro-n-(2-chloro-4-methylpyridin-3-yl)nicotinamide;2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide;2-CHLORO-N-(2-CHLORO-4-METHYL-PYRIDIN-3-YL)NICOTINAMIDE, 98+%;2-Chloro-N-(2-Chloro-4-Methyl-3-Pyridinly)-3-Pyridinecarboxamide;Nevirapine InterMediate;Picnic;2-chloro-N-(2-chloro-4-Methylpyridin-3-yl)pyridine-3-carboxaMide
• CAS NO: 133627-46-0
• Molecular Formula: C₁₂H₉Cl₂N₃O
• Molecular Weight: 282.13
• EINECS: 1312995-182-4
• Product Categories: Nucleotides and Nucleosides;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
• Mol File: 133627-46-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 189-191°C
• Boiling Point: 369.848 °C at 760 mmHg
• Flash Point: 177.478 °C
• Appearance: Pale yellow solid
• Density: 1.447 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.656
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 10.20±0.70(Predicted)
• CAS DataBase Reference: 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide(133627-46-0)
• EPA Substance Registry System: 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide(133627-46-0)

Safety Data

• Hazardous Substances Data: 133627-46-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 133627-46-0 differently. You can refer to the following data:
1. An intermediate in the synthesis of Nivirapine
2. An intermediate in the synthesis of Nivirapine.

InChI:InChI=1/C12H9Cl2N3O/c1-7-4-6-16-11(14)9(7)17-12(18)8-3-2-5-15-10(8)13/h2-6H,1H3,(H,17,18)

Upstream product

• 133627-45-9 3-Amino-2-chloro-4-methylpyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 2942-59-8 2-chloronicotinic acid 
• 49609-84-9 2-Chloronicotinoyl chloride 

Downstream Products

• 129618-40-2 Nevirapine 
• 1051418-95-1 d4-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one 
• 1198294-86-8 C₂₁H₂₁ClN₄O₃ 
• 133627-17-5 5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one 
• 133627-47-1 N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide 

Relevant articles and documents

Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing

Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.

AN IMPROVED PROCESS FOR INDUSTRIAL MANUFACTURE OF NEVIRAPINE

An improved cost-effective, environmental friendly, industrial method for manufacture of Nevirapine.Formula (I):

Structural elucidation of an oxazolo[5,4-b]pyridine: An alternative cyclization product related to nevirapine

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