13366-36-4

Basic information

• Product Name: dimethylstilbestrol
• Synonyms: dimethylstilbestrol
• CAS NO: 13366-36-4
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Mol File: 13366-36-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 381°C at 760 mmHg
• Flash Point: 178.8°C
• Appearance: /
• Density: 1.148g/cm³
• Vapor Pressure: 2.39E-06mmHg at 25°C
• Refractive Index: 1.624
• CAS DataBase Reference: dimethylstilbestrol(CAS DataBase Reference)
• NIST Chemistry Reference: dimethylstilbestrol(13366-36-4)
• EPA Substance Registry System: dimethylstilbestrol(13366-36-4)

Safety Data

• Hazardous Substances Data: 13366-36-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O2/c1-11(13-3-7-15(17)8-4-13)12(2)14-5-9-16(18)10-6-14/h3-10,17-18H,1-2H3/b12-11+

Upstream product

• 17324-35-5 (E)-2,3-di(4-methoxyphenyl)-2-butene 
• 4091-39-8 3-chloro-2-butanone 
• 108-95-2 phenol 
• 141-78-6 ethyl acetate 
• 99-93-4 4-Hydroxyacetophenone 
• 108-24-7 acetic anhydride 

Downstream Products

• 1229404-09-4 E-4,4'-(1,2-dimethyl-1,2-ethenediyl)bis[2-[(dimethylamino)methyl]phenol] 
• 15624-00-7 (+/-)-threo-2-<4-(2-Diethylamino-ethoxy)-phenyl>-3-(4-hydroxy-phenyl)-butan 
• 15515-43-2 (+/-)-erythro-2-<4-(2-Dimethylamino-ethoxy)-phenyl>-3-(4-methoxy-phenyl)-butan 
• 65026-54-2 d,l-2,3-bis(4-methoxyphenyl)butane 
• 109972-19-2 trans-4-(2-Diethylamino-ethoxy)-4'-methoxy-α,α'-dimethyl-stilben 
• 109972-20-5 trans-4-Methoxy-α,α'-dimethyl-4'-(2-dimethylamino-ethoxy)-stilben 
• 109972-25-0 4-(2-{4-[2-(4-methoxy-phenyl)-1-methyl-propenyl]-phenoxy}-ethyl)-morpholine 
• 17324-35-5 (E)-2,3-di(4-methoxyphenyl)-2-butene 
• 21852-74-4 trans-4,4'-Bis-(2-diethylamino-ethoxy)-α,α'-dimethyl-stilben 
• 15542-02-6 trans-4'-(2-Diethylamino-ethoxy)-α,α'-dimethyl-stilben-4-ol 
• 99-93-4 4-Hydroxyacetophenone 
• 15542-13-9 4,4'-{2,2'-[4,4'-(1,2-dimethyl-ethene-1,2-diyl)-diphenoxy]-diethyl}-bis-morpholine 
• 2962-14-3 racem.-2,3-bis-(4-hydroxy-phenyl)-butane 

Related news

dimethylstilbestrol (cas 13366-36-4) and 16-oxo-estradiol: Anti-estrogens or estrogens?07/24/2019

A dose of dimethylstilbestrol, which is anti-estrogenic when given as a single intravaginal injection, produces all the vaginal changes characteristic of estrogen action when given as 1 or 2 series of 10 1-hourly injections. Similar results were obtained with 16-oxo-estradiol given in 1 or 2 ser...detailed

Relevant articles and documents

Low-valent titanium mediated synthesis of hydroxystilbenoids: Some new observations

A series of phenolic stilbenoids possessing different numbers and positions of hydroxylation, partial methoxyl substituents and nature of olefinic moieties has been synthesized by McMurry coupling. It is found that the McMurry coupling of the phenolic aldehydes furnishes the dihydrostilbenes via an in situ hydrogenation, while the phenolic ketones give the stilbenes. Interestingly, the study also reveals that the low-valent titanium reagent (TiCl 3-Zn-THF) could selectively depyranylate phenolic -OTHP function without affecting alcoholic -OTHP group.

Method for preparing aromatic bischloroformate compositions

Bischloroformate oligomer compositions are prepared by passing phosgene into a heterogeneous aqueous-organic mixture containing at least one dihydroxyaromatic compound, with simultaneous introduction of a base at a rate to maintain a specific pH range and to produce a specific volume ratio of aqueous to organic phase. By this method, it is possible to employ a minimum amount of phosgene. The reaction may be conducted batchwise or continuously. The bischloroformate composition may be employed for the preparation of cyclic polycarbonate oligomers or linear polycarbonate, and linear polycarbonate formation may be integrated with bischloroformate composition formation in a batch or continuous process.

Bischoloroformate preparation method with phosgene removal and monochloroformate conversion

Aqueous bischloroformates are prepared by the reaction of a dihydroxyaromatic compound (e.g., bisphenol A) with phosgene in a substantially inert organic liquid (e.g., methylene chloride) and in the presence of an aqueous alkali metal or alkaline earth metal base, at a pH below about 8. After all solid dihydroxyaromatic compound has been consumed, the pH is raised to a higher value in the range of about 7-12, preferably 9-11, and maintained in said range until a major proportion of the unreacted phosgene has been hydrolyzed. At the same time, any monochloroformate in the product may be converted to bischloroformate.