1337531-36-8

Basic information

• Product Name: 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine
• Synonyms: 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine;7-Methyl-5-[1-[[3-(trifluoromethyl)phenyl]acetyl]-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine GSK2606414;GSK2606414/ 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine;GSK2606414, >=98%;GSK2606414 (Free base);1-(5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-indolin-1-yl)-2-(3-(trifluoromethyl)ph;1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone
• CAS NO: 1337531-36-8
• Molecular Formula: C₂₄H₂₀F₃N₅O
• Molecular Weight: 451.46
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 1337531-36-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 720.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.43±0.1 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 5.76±0.30(Predicted)
• CAS DataBase Reference: 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine(1337531-36-8)
• EPA Substance Registry System: 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine(1337531-36-8)

Safety Data

• Hazardous Substances Data: 1337531-36-8(Hazardous Substances Data)

Usage

Description

7Methyl-5-(1-[3-(trifluoroMethyl)phenyl]acetyl-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine is a complex organic compound with a unique molecular structure. It is characterized by its indole and pyrrolo[2,3-d]pyrimidine moieties, which contribute to its potential biological activities. The presence of a trifluoromethyl group and a methyl group further modulate its properties, making it an interesting candidate for various applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
7Methyl-5-(1-[3-(trifluoroMethyl)phenyl]acetyl-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine is used as a potent and selective inhibitor of protein kinase R and endoplasmic reticulum kinase. Its application in this field is due to its ability to affect numerous diseases, such as cancer, by modulating cellular signaling pathways and disrupting the activity of key enzymes involved in disease progression.
Used in Drug Development:
In the drug development sector, 7Methyl-5-(1-[3-(trifluoroMethyl)phenyl]acetyl-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine serves as a promising lead compound for the design and synthesis of novel therapeutic agents. Its unique structure and potential biological activities make it a valuable starting point for the development of new drugs targeting various diseases, including cancer and other conditions related to protein kinase R and endoplasmic reticulum kinase dysregulation.
Used in Chemical Research:
7Methyl-5-(1-[3-(trifluoroMethyl)phenyl]acetyl-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine is also utilized in chemical research as a model compound for studying the synthesis, reactivity, and properties of complex organic molecules. Its unique structure provides opportunities for exploring new synthetic routes, understanding the influence of functional groups on molecular properties, and investigating potential applications in various fields, such as materials science and supramolecular chemistry.

Upstream product

• 1266343-30-9 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine 
• 7781-10-4 4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin 
• 261732-38-1 tert-butyl 5-bromoindoline-1-carboxylate 
• 837392-67-3 1,1-dimethylethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole-1-carboxylate 
• 1391053-27-2 1,1-dimethylethyl 5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indole-1-carboxylate 
• 22190-33-6 5-bromoindoline 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 1337532-51-0 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337533-85-3 5-(2,3-dihydro-1H-indol-5-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride 
• 351-35-9 3-(trifluoromethyl)phenylacetic acid 

Relevant articles and documents

COMPOUNDS AND METHODS FOR TREATING INSULIN RESISTANCE SYNDROME

The present invention relates to a method of treating or preventing insulin resistance syndrome in an animal body by administering an inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK) gene, or a functional variant thereof, or an inhibitor of PERK protein or a functional variant thereof or a method of reducing activity of transcription factors of the FOXO family (Foxo 1, 3a, 4 and 6) by administering an inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK) gene, or a functional variant thereof, or an inhibitor of PERK protein or a functional variant thereof. The present invention also relates to different compounds and methods for using PERK gene or PERK protein.