133776-50-8

Basic information

• Product Name: Benzonitrile, 4-(2-aminobenzoyl)-
• CAS NO: 133776-50-8
• Molecular Formula: C14H10N2O
• Molecular Weight: 222.246
• Mol File: 133776-50-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-(2-aminobenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-(2-aminobenzoyl)-(133776-50-8)
• EPA Substance Registry System: Benzonitrile, 4-(2-aminobenzoyl)-(133776-50-8)

Safety Data

• Hazardous Substances Data: 133776-50-8(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 

Downstream Products

• 1449372-79-5 4-(3-acetyl-2-oxo-1,2-dihydroquinolin-4-yl)benzonitrile 
• 1449373-15-2 (E)-4-(3-(3-(4-chlorophenyl)acryloyl)-2-oxo-1,2-dihydroquinolin-4-yl)benzonitrile 
• 1449374-04-2 4-{5-(4-chlorophenyl)-3-[4-(4-cyanophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]-4,5-dihydro-1H-pyrazol-1-yl}-4-oxobutanoic acid 
• 1449373-60-7 4-{3-[5-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]-2-oxo-1,2-dihydroquinolin-4-yl}benzonitrile 

Relevant articles and documents

Method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid

Disclosed is a method for synthesizing ortho-amino aromatic ketone from aromatic carboxylic acid. The method comprises the steps that with 2-arylsulfonamido aromatic carboxylic acid shown in the description as a raw material and triphenylphosphine as a deoxidizer, under the illumination of blue light, in a 1,4-dioxane solution, under an argon atmosphere, in the presence of the dipotassium hydrogenphosphate, with [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 as a photocatalyst, the ortho-amino aromatic ketone compound is obtained; the structure of the photocatalyst [Ir(dF(CF3)ppy)2(dtbbpy)]PF6 is shown in thedescription.

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists

Here we describe the synthesis and structure-activity relationship for a class of pyrazoline-containing dihydroquinolone negative allosteric modulators of the NMDA receptor that show strong subunit selectivity for GluN2C- and GluN2D-containing receptors over GluN2A- and GluN2B-containing receptors. Several members of this class inhibit NMDA receptor responses in the nanomolar range and are more than 50-fold selective over GluN1/GluN2A and GluN1/GluN2B NMDA receptors, as well as AMPA, kainate, GABA, glycine, nicotinic, serotonin, and purinergic receptors. Analysis of the purified enantiomers of one of the more potent and selective compounds shows that the S-enantiomer is both more potent and more selective than the R-enantiomer. The S-enantiomer had an IC 50 of 0.17-0.22 μM at GluN2D- and GluN2C-containing receptors, respectively, and showed over 70-fold selectivity over other NMDA receptor subunits. The subunit selectivity of this class of compounds should be useful in defining the role of GluN2C- and GluN2D-containing receptors in specific brain circuits in both physiological and pathophysiological conditions.