133806-59-4

Basic information

• Product Name: purpactin A
• Synonyms: purpactin A;Acetic acid 1-(4-acetyl-11-hydroxy-9-methyl-5-oxo-5H,7H-dibenzo[b,g][1,5]dioxocin-3-yl)-3-methylbutyl ester;AS-186b
• CAS NO: 133806-59-4
• Molecular Formula: C23H26O7
• Molecular Weight: 414.45
• Mol File: 133806-59-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 601.6°C at 760 mmHg
• Flash Point: 206.2°C
• Appearance: /
• Density: 1.223g/cm³
• Vapor Pressure: 4.55E-15mmHg at 25°C
• Refractive Index: 1.56
• PKA: 8.56±0.20(Predicted)
• CAS DataBase Reference: purpactin A(CAS DataBase Reference)
• NIST Chemistry Reference: purpactin A(133806-59-4)
• EPA Substance Registry System: purpactin A(133806-59-4)

Safety Data

• Hazardous Substances Data: 133806-59-4(Hazardous Substances Data)

Usage

Description

Purpactin A, also known as the 1'-O-acetyl derivative of penicillide, is a dibenzodioxocine compound isolated from Penicillium purpurogenum. It functions as an inhibitor of acyl-CoA:cholesterol acyltransferase, a key enzyme involved in cholesterol metabolism.

Uses

Used in Pharmaceutical Industry:
Purpactin A is used as a pharmaceutical agent for its cholesterol-lowering properties. It inhibits the enzyme acyl-CoA:cholesterol acyltransferase, which plays a crucial role in cholesterol synthesis and metabolism. By inhibiting this enzyme, purpactin A can potentially help in the development of treatments for hypercholesterolemia and related cardiovascular diseases.
Used in Research Applications:
Purpactin A is also used as a research tool in the study of cholesterol metabolism and the role of acyl-CoA:cholesterol acyltransferase in various biological processes. It can be employed to investigate the effects of inhibiting this enzyme on cellular functions and to understand the underlying mechanisms of cholesterol-related diseases.
Used in Drug Development:
In the field of drug development, purpactin A serves as a lead compound for the design and synthesis of new drugs targeting cholesterol metabolism. Its inhibitory activity against acyl-CoA:cholesterol acyltransferase can be leveraged to develop more potent and selective inhibitors, which may have improved therapeutic potential for treating hypercholesterolemia and other cholesterol-related conditions.

InChI:InChI=1/C23H26O7/c1-12(2)8-19(29-14(4)24)16-6-7-18-20(22(16)27-5)23(26)28-11-15-9-13(3)10-17(25)21(15)30-18/h6-7,9-10,12,19,25H,8,11H2,1-5H3