1338361-32-2

Basic information

• Product Name: 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl chloride
• Synonyms: 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl chloride
• CAS NO: 1338361-32-2
• Molecular Weight: 284.145
• Mol File: 1338361-32-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl chloride(1338361-32-2)
• EPA Substance Registry System: 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl chloride(1338361-32-2)

Safety Data

• Hazardous Substances Data: 1338361-32-2(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 1017444-93-7 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carboxylic acid 
• 1613396-45-4 C₁₃H₁₄ClN₃O₂ 
• 3296-05-7 1-azido-4-chlorobenzene 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 

Downstream Products

• 1613397-04-8 (3S)-1-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one trifluuoroacetate 
• 1613396-48-7 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl azide 
• 1503894-95-8 1-(4-chlorophenyl)-5-isopropyl-tiazol-4-amine 
• 1613396-51-2 (2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide 
• 1613396-53-4 [(3S)-4-[[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]amino]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]-4-oxo-butyl]methanesulfonate 

Relevant articles and documents

Primary discovery of 1-aryl-5-substituted-1H-1,2,3-triazole-4-carboxamides as promising antimicrobial agents

Three series of novel 1H-1,2,3-triazole-4-carboxamides: 1-aryl-5-alkyl/aryl-1H-1,2,3-triazole-4-carboxamides, 1-aryl-5-amino-1H-1,2,3-triazole-4-carboxamides and 1,2,3-triazolo[1,5-a]quinazoline-3-carboxamides were synthesized via base-mediated click azide reactions. Compounds were evaluated for their antimicrobial activities against primary pathogens: Gram-positive and Gram-negative bacterial strains Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, as well as fungal strain Cryptococcus neoformans var. grubii and Candida albicans. Compounds exhibiting moderate to good activities were selected for SAR analysis. Several 5-methyl-1H-1,2,3-triazole-4-carboxamides 4d, 4l, 4r, showed potent antibacterial effect against S. aureus. On the contrary, 5-amino-1H-1,2,3-triazole-4-carboxamide 8b and [1,2,3]triazolo[1,5-a]quinazoline-3-carboxamide 9a were active against pathogenic yeast C. albicans. Thus, compound 4l under 1 μM demonstrated 50% growth inhibition against S. aureus. At the same concentration, the compound 9a killed approx. 40% of C. albicans cells. In general, these compounds demonstrated selective action and no significant impact on the viability of human keratinocytes of HaCaT line.