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1338545-07-5

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1338545-07-5 Usage

Description

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM), which specifically blocks cytokinesis, leading to apoptosis in a broad range of cancer cells. It has demonstrated the ability to induce apoptosis of human lung cancer cells in mouse xenografts.

Uses

Used in Anticancer Applications:
OTS964 is used as an anticancer agent for its ability to effectively inhibit TOPK, leading to tumor suppression in xenografts of human cancer. It works through cytokinesis, causing apoptosis in a wide variety of cancer cells, making it a promising candidate for cancer treatment.
Used in Pharmaceutical Industry:
OTS964 is used as a pharmaceutical compound for its potential in developing targeted cancer therapies. Its specificity in blocking cytokinesis and inducing apoptosis in cancer cells suggests that it could be a valuable asset in the development of new cancer treatments with fewer side effects and higher efficacy.

references

1. matsuo y, park jh2, miyamoto t, et al. topk inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. ci transl med. 2014 oct 22;6(259):259ra145.

Check Digit Verification of cas no

The CAS Registry Mumber 1338545-07-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,8,5,4 and 5 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1338545-07:
(9*1)+(8*3)+(7*3)+(6*8)+(5*5)+(4*4)+(3*5)+(2*0)+(1*7)=165
165 % 10 = 5
So 1338545-07-5 is a valid CAS Registry Number.

1338545-07-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one hydrochloride

1.2 Other means of identification

Product number -
Other names OTS-964

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1338545-07-5 SDS

1338545-07-5Upstream product

1338545-07-5Downstream Products

1338545-07-5Relevant articles and documents

TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME

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Page/Page column 283-284, (2011/10/13)

Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.

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