13414-56-7

Basic information

• Product Name: 2,3-DIHYDROBENZO[B]FURAN-7-YLAMINE
• Synonyms: 7-Amino-2,3-dihydrobenzofuran;2,3-dihydrobenzofuran-7-amine hydrochloride;2,3-DIHYDROBENZO[B]FURAN-7-YLAMINE;2,3-Dihydro-1-benzofuran-7-amine;2,3-dihydrobenzofuran-7-aMine;2,3-Dihydro-benzofuran-7-ylamine
• CAS NO: 13414-56-7
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.17
• Mol File: 13414-56-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 271.063 °C at 760 mmHg
• Flash Point: 136.589 °C
• Appearance: /
• Density: 1.208 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.66±0.20(Predicted)
• CAS DataBase Reference: 2,3-DIHYDROBENZO[B]FURAN-7-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDROBENZO[B]FURAN-7-YLAMINE(13414-56-7)
• EPA Substance Registry System: 2,3-DIHYDROBENZO[B]FURAN-7-YLAMINE(13414-56-7)

Safety Data

• Hazardous Substances Data: 13414-56-7(Hazardous Substances Data)

Usage

General Description

2,3-Dihydrobenzo[b]furan-7-ylamine is a chemical compound with the molecular formula C10H11NO. It is a member of the benzofuran family and contains a furan ring with an amine group attached to it. 2,3-Dihydrobenzo[b]furan-7-ylamine is commonly used in organic synthesis and pharmaceutical research as a building block for the preparation of various biologically active molecules and heterocyclic compounds. It has also been studied for its potential therapeutic applications, particularly in the field of drug discovery. Overall, 2,3-Dihydrobenzo[b]furan-7-ylamine is an important and versatile chemical with various potential uses in the field of organic chemistry and pharmaceuticals.

Upstream product

• 496-16-2 2.3-dihydrobenzofuran 
• 35700-40-4 2,3-dihydrobenzofuran-7-carboxylic acid 

Relevant articles and documents

Synthesis and SAR of highly potent dual 5-HT1A and 5-HT 1B antagonists as potential antidepressant drugs

Novel 5-HT1 autoreceptor ligands based on the N-4-aryl-piperazinyl-N′-ethyl-5,6,7,8-tetrahydropyrido[4′, 3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-one core are described. Aiming at antidepressants with a novel mode of action our objective was to identify potent antagonists showing balanced affinities and high selectivity for the 5-HT 1A and 5-HT1B receptors. Strategies for the development of dual 5-HT1A and 5-HT1B antagonists based on 1 and 2 as leads and the corresponding results are discussed. Isoquinoline analogue 33 displayed high affinity and an antagonistic mode of action for the 5-HT 1A and the 5-HT1B receptors and was characterized further with respect to selectivity, electrically stimulated [3H]5-HT release and in vivo efficacy.

2, 4- DI (PHENYLAMINO) PYRIMIDINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS

Novel pyrimidine derivatives of formula (I), to processes for their production, their use as pharmaceuticals in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.