134220-37-4

Basic information

• Product Name: 1-(3-CHLORO-4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE
• Synonyms: 1-(3-Chloro-4-fluorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione;1-(3-chloro-4-fluoro-phenyl)-3-pyrroline-2,5-quinone
• CAS NO: 134220-37-4
• Molecular Formula: C₁₀H₅ClFNO₂
• Molecular Weight: 225.61
• Mol File: 134220-37-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 367.2 °C at 760 mmHg
• Flash Point: 175.9 °C
• Appearance: /
• Density: 1.54 g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-CHLORO-4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE(134220-37-4)
• EPA Substance Registry System: 1-(3-CHLORO-4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE(134220-37-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 134220-37-4(Hazardous Substances Data)

Usage

General Description

1-(3-chloro-4-fluoro-phenyl)-pyrrole-2,5-dione, also known as a chlorofluorophenyl-pyrroledione, is a chemical compound with the molecular formula C10H5ClFNO2. It is a pyrrole-2,5-dione derivative, with a phenyl ring attached to the pyrrole ring at the 1 position and substituted with a chlorine atom at the 3 position and a fluorine atom at the 4 position. 1-(3-CHLORO-4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE has potential applications in the field of medicinal chemistry due to its unique structure and potential biological activities. It may be used as a starting material for the synthesis of other compounds with pharmaceutical properties or as a pharmacophore for developing new drugs. Additionally, it can be used as a reference standard in analytical chemistry for the identification and quantification of related compounds in various samples.

InChI:InChI=1/C10H5ClFNO2/c11-7-5-6(1-2-8(7)12)13-9(14)3-4-10(13)15/h1-5H

Upstream product

• 108-31-6 maleic anhydride 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 196804-60-1 C₁₀H₇ClFNO₃ 

Downstream Products

• 1229020-51-2 C₂₉H₄₁ClFN₃O₃ 
• 457639-84-8 3,4-dichloro-1-(3-chloro-4-fluorophenyl)-1H-pyrrole-2,5-dione 
• 457640-23-2 3-chloro-1-(3-chloro-4-fluorophenyl)-4-morpholino-1H-pyrrole-2,5-dione 
• 1016982-29-8 1-(3-chloro-4-fluorophenyl)-3-phenylpyrrolidine-2,5-dione 
• 74894-65-8 1-(3-Chloro-4-fluoro-phenyl)-3-[1-ethoxy-meth-(E)-ylidene]-pyrrolidine-2,5-dione 

Relevant articles and documents

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.

An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity

Homologous recombination (HR) is an essential process in cells that provides repair of DNA double-strand breaks and lesions that block DNA replication. RAD51 is an evolutionarily conserved protein that is central to HR. Overexpression of RAD51 protein is