1344693-19-1Relevant articles and documents
Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity
Stokes, Suzanne S.,Huynh, Hoan,Gowravaram, Madhusudhan,Albert, Robert,Cavero-Tomas, Marta,Chen, Brendan,Harang, Jenna,Loch III, James T.,Lu, Min,Mullen, George B.,Zhao, Shannon,Liu, Ce-Feng,Mills, Scott D.
, p. 4556 - 4560 (2011/09/15)
Optimization of adenosine analog inhibitors of bacterial NAD +-dependent DNA ligase is discussed. Antibacterial activity against Streptococcus pneumoniae and Staphylococcus aureus was improved by modification of the 2-position substituent on the adenine ring and 3′- and 5′-substituents on the ribose. Compounds with log D values 1.5-2.5 maximized potency and maintained drug-like physical properties.