1346599-45-8 Usage
Description
Azilsartan-d5 is a deuterated analog of Azilsartan, which is an angiotensin II receptor blocker (ARB) used in the treatment of hypertension. It is a white solid and is labeled for use in analgesic and anti-inflammatory drugs containing angiotensin II antagonists. The deuterium labeling in Azilsartan-d5 aids in the study of its chemical and biological properties, making it a valuable tool in research and development.
Uses
Used in Pharmaceutical Industry:
Azilsartan-d5 is used as a research compound for the development of new drugs targeting the renin-angiotensin system. Its deuterated nature allows for the investigation of the metabolic pathways and pharmacokinetics of Azilsartan, potentially leading to the discovery of more effective and safer antihypertensive medications.
Used in Analytical Chemistry:
Azilsartan-d5 serves as an internal standard in analytical chemistry, particularly in liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) applications. The stable isotope labeling enhances the accuracy and precision of quantitative measurements, making it a valuable tool for the analysis of angiotensin II receptor blockers in biological samples.
Used in Drug Metabolism Studies:
In the field of drug metabolism, Azilsartan-d5 is used as a labeled reference compound to study the metabolic fate of Azilsartan in the body. This information is crucial for understanding the drug's pharmacokinetics, bioavailability, and potential drug-drug interactions, ultimately contributing to the optimization of its therapeutic use.
Used in Toxicology Research:
Azilsartan-d5 is employed in toxicology research to investigate the potential toxic effects of Azilsartan and its metabolites. By comparing the behavior of the deuterated compound with that of the non-deuterated parent molecule, researchers can gain insights into the mechanisms of toxicity and identify potential strategies to mitigate adverse effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1346599-45-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,4,6,5,9 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1346599-45:
(9*1)+(8*3)+(7*4)+(6*6)+(5*5)+(4*9)+(3*9)+(2*4)+(1*5)=198
198 % 10 = 8
So 1346599-45-8 is a valid CAS Registry Number.