13466-38-1

Basic information

• Product Name: 2-Hydroxy-5-bromopyridine
• Synonyms: 2-Hydroxy-5-bromopyridine ,97%;2-Hydroxy-5-broMopyridine, 99% 25GR;2-Hydroxy-5-broMopyridine, 99% 5GR;5-Bromo-2-pyridinol 5-Bromo-2(1H)-pyridinone 5-Bromo-2-pyridone;5-Bromopyridin-2-ol, 5-Bromopyridin-2(1H)-one;2-hydroxy -5-pyridyl broMide;5-BroMo-1H-pyridin-2-one;5-Bromo-2(1H)-pyridone 97%
• CAS NO: 13466-38-1
• Molecular Formula: C₅H₄BrNO
• Molecular Weight: 174
• EINECS: -0
• Product Categories: blocks;Bromides;Pyridines;Pyridine;Alcohols and Derivatives;Heterocycles;Pyridine Series;Halides;Bromopyridines;Halopyridines;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 13466-38-1.mol
• Article Data: 24

Chemical Properties

• Melting Point: 180-183 °C(lit.)
• Boiling Point: 305.9 ºC at 760 mmHg
• Flash Point: 138.8 ºC
• Appearance: Off-white to yellow-brown/Crystalline Powder
• Density: 1.776 g/cm³
• Vapor Pressure: 0.000796mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.96±0.10(Predicted)
• BRN: 108751
• CAS DataBase Reference: 2-Hydroxy-5-bromopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-5-bromopyridine(13466-38-1)
• EPA Substance Registry System: 2-Hydroxy-5-bromopyridine(13466-38-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 13466-38-1(Hazardous Substances Data)

Usage

Chemical Properties

off-white to yellow-brown crystalline powder

General Description

5-Bromo-2(1H)-pyridone undergoes difluormethylation in the presence of sodium chlorodifluoroacetate (ClCF2COONa) and methyl cyanide.

InChI:InChI=1/C5H4BrNO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8)

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 504-29-0 2-aminopyridine 
• 142-08-5 2-hydroxypyridin 
• 1072-97-5 5-bromo-2-pyridylamine 
• 1493-13-6 trifluorormethanesulfonic acid 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 122256-50-2 1-benzyloxy-5-bromo-2-pyridone 
• 53939-30-3 5-bromo-2-chloropyridine 
• 109-09-1 2-chloropyridine 
• 83664-33-9 2-(benzyloxy)-5-bromopyridine 
• 39856-50-3 5-bromo2-nitropyridine 
• 51933-78-9 5-bromo-2-(methylsulfanyl)pyridine 
• 856849-02-0 2-benzyloxy-5-bromo-pyridine-1-oxide 

Downstream Products

• 79674-66-1 2-((5-bromopyridin-2-yl)oxy)acetic acid 
• 381233-75-6 5-bromo-2-hydroxy-3-iodopyridine 
• 426823-58-7 5-bromo-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyridin-2-one 
• 882170-27-6 [1-(5-bromo-pyridin-2-yloxymethyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 899452-26-7 5-bromo-2-(difluoromethoxy)pyridine 
• 832735-61-2 5-bromo-1-(difluoromethyl)-1,2-dihydropyridin-2-one 
• 870521-31-6 5-bromo-2-isopropoxy-pyridine 
• 1051316-00-7 1-(2-(benzyloxy)ethyl)-5-bromopyridin-2(1H)-one 
• 851087-08-6 5-bromo-1-isopropylpyridine-2(1H)-one 
• 1114573-41-9 5-bromo-1-(cyclopropylmethyl)-1,2-dihydropyridin-2-one 
• 1438246-42-4 cis-4-{[5-(1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylic acid 
• 1442646-19-6 cis-4-{[5-(5-fluoro-1H-benzimidazol-2-yl)-2,3'-bipyridin-6'-yl]oxy}cyclohexanecarboxylic acid 
• 1438246-07-1 C₂₄H₂₀F₂N₄O₃ 
• 1442646-34-5 trans-4-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclohexanecarboxylic acid 

Relevant articles and documents

Preparation method of 2, 5-dibromopyridine

The invention discloses a preparation method of 2, 5-dibromopyridine, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: reacting 2-hydroxypyridine serving as a raw material with a bromination reagent to obtain 2-hydroxy-5-bromopyridine; and then reacting with a bromination reagent under the action of a Lewis acid catalyst to obtain 2, 5-dibromopyridine. The method is completed in two steps, an isomer obtained in the first step of reaction does not need to be purified, and a product with the purity of 99.5% or above can be obtained through recrystallization once in the last step.

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PYRIDONE DERIVATIVE COMPRISING HETEROATOMIC RING BUTANE SUBSTITUENT, FOR TREATING FIBROSIS AND INFLAMMATORY DISEASES

Disclosed is a compound for treating fibrosis-related diseases, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof.