1347750-75-7

Basic information

• Product Name: Boc-9-AMino-4,7-Dioxanonanoic acid
• Synonyms: Boc-9-AMino-4,7-Dioxanonanoic acid;Boc-NH-PEG3-CH2CH2COOH;t-Boc-N-amido-PEG3-acid;Boc-PEG3- CH2 CH2COOH;5,8,11-Trioxa-2-azatetradecanedioic acid 1-(1,1-dimethylethyl) ester;Boc-N-amido-PEG3-acid;t-boc-N-amido-PEG3-propionic acid
• CAS NO: 1347750-75-7
• Molecular Formula: C12H23NO6
• Molecular Weight: 277.31412
• Product Categories: PEGylated Amino Acid
• Mol File: 1347750-75-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 471.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.124±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol(Sparingly)
• PKA: 4.28±0.10(Predicted)
• CAS DataBase Reference: Boc-9-AMino-4,7-Dioxanonanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-9-AMino-4,7-Dioxanonanoic acid(1347750-75-7)
• EPA Substance Registry System: Boc-9-AMino-4,7-Dioxanonanoic acid(1347750-75-7)

Safety Data

• Hazardous Substances Data: 1347750-75-7(Hazardous Substances Data)

Usage

Description

Boc-9-AMino-4,7-Dioxanonanoic acid, also known as t-Boc-N-amido-PEG3-acid, is a PEG linker that contains a terminal carboxylic acid and a Boc-protected amino group. The hydrophilic PEG spacer enhances solubility in aqueous media, while the terminal carboxylic acid can react with primary amine groups to form a stable amide bond in the presence of activators such as EDC or HATU. The Boc group can be deprotected under mild acidic conditions, resulting in the formation of a free amine.

Uses

Used in Pharmaceutical Industry:
Boc-9-AMino-4,7-Dioxanonanoic acid is used as a building block for the synthesis of various pharmaceutical compounds. The expression is: Boc-9-AMino-4,7-Dioxanonanoic acid is used as a building block for [pharmaceutical compound synthesis] because of its ability to form stable amide bonds with primary amine groups and its Boc-protected amino group that can be deprotected under mild acidic conditions.
Used in Drug Delivery Systems:
In the field of drug delivery, Boc-9-AMino-4,7-Dioxanonanoic acid is used as a component in the development of targeted drug delivery systems. The expression is: Boc-9-AMino-4,7-Dioxanonanoic acid is used as a component in [targeted drug delivery systems] for its ability to enhance solubility and facilitate the formation of stable amide bonds, which can be crucial in the design and synthesis of drug conjugates and prodrugs.
Used in Bioconjugation:
Boc-9-AMino-4,7-Dioxanonanoic acid is also utilized in bioconjugation processes, where it serves as a linker between biological molecules and other entities, such as drugs or imaging agents. The expression is: Boc-9-AMino-4,7-Dioxanonanoic acid is used as a linker in [bioconjugation processes] due to its hydrophilic PEG spacer and reactive terminal carboxylic acid, which can form stable amide bonds with primary amine groups on biological molecules.