134859-12-4Relevant articles and documents
Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation
Zhu, Weiping,Dai, Min,Xu, Yufang,Qian, Xuhong
, p. 3255 - 3260 (2008)
Based on the principle that the nitro-group can quench the fluorescence and can be reduced under hypoxic conditions, several novel nitroheterocyclic compounds without 2-nitroimidazole as potential hypoxic markers were prepared. Although they were synthesized from the same matrix, nitrosubstituted acenaphtho[1,2-b]quinoxaline, these compounds exhibited quite different fluorescence changes when they were differently nitrosubstituted. Their evaluation for imaging tumor hypoxia was carried out in V79 cells in vitro by Fluorescence Microplate Reader. After 3.5 h, the hypoxic-oxic fluorescence differential incubated with A1, A4, and A5 in V79 cells could reach 6, 9, and 11 times differential fluorescence between oxic and hypoxic cells separately, which are suitable for further evaluation as probes for hypoxic cells in tumors in vivo.
Fluorescent probes for detecting concentration of nitric oxide, and synthesis method and application thereof
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Paragraph 0009; 0063-0064, (2020/06/02)
The invention belongs to the technical fields of organic synthesis and fluorescent probe detection, and discloses fluorescent probes for detecting the concentration of nitric oxide, and a synthesis method and an application thereof. The fluorescent probes are named as AQA (including a fluorescent probe A: AQA-H, a fluorescent probe B: AQA-OCH3, a fluorescent probe C: AQA-Cl and a fluorescent probeD: AQA-Br). The fluorescent probes AQA have an excitation wavelength of 400-430 nm and an emission wavelength of 480-620 nm; and each fluorescent probe has large Stokes shift. In in-vitro nitric oxide detection, the fluorescent probes AQA have high reaction sensitivity with nitric oxide, and are significant in fluorescence intensity change. According to the invention, the reaction conditions of AQA and NO are screened; and the fluorescence response of AQA-OCH3 and NO under physiological conditions (a pH value of 7.4 and a temperature of 25 DEG C) is discovered to be the best.
Synthesis of benzimidazole and quinoxaline derivatives using reusable sulfonated rice husk ash (RHA-SO3H) as a green and efficient solid acid catalyst
Shamsi-Sani, Mahnaz,Shirini, Farhad,Abedini, Masoumeh,Seddighi, Mohadeseh
, p. 1091 - 1099 (2016/04/26)
In this work, a simple, rapid and efficient method for the preparation of benzimidazoles and quinoxalines from the condensation of o-phenylene diamines with aldehydes and/or 1,2-dicarbonyl compounds in the presence of sulfonated rice husk ash (RHA-SO3H) as an efficient green catalyst is reported. RHA-SO3H can be easily prepared using a readily available organic compound by simple modification of rice husk ash. All reactions are performed under mild reaction conditions with high to excellent yields. The method is applicable to aromatic, unsaturated and hetero aromatic aldehydes. The advantages of this method are short reaction times, milder conditions, easy work-up, solvent-free conditions and catalyst reusability.
