1350475-42-1

Basic information

• Product Name: 1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate
• Synonyms: 1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate;1-Boc-4-(Cyanomethyl)-4-Piperidine Carboxylic Acid Methyl Ester(WX618324)
• CAS NO: 1350475-42-1
• Molecular Formula: C14H22N2O4
• Molecular Weight: 282.33548
• Mol File: 1350475-42-1.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate(1350475-42-1)
• EPA Substance Registry System: 1-tert-butyl 4-methyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate(1350475-42-1)

Safety Data

• Hazardous Substances Data: 1350475-42-1(Hazardous Substances Data)

Usage

Explanation

TAPP consists of 14 carbon atoms, 24 hydrogen atoms, 2 nitrogen atoms, and 4 oxygen atoms.

Explanation

The core structure of TAPP is a piperidine ring, which is a six-membered nitrogen-containing heterocyclic ring.

Explanation

TAPP has a tert-butyl and a methyl group attached to the nitrogen atom of the piperidine ring, and a cyanomethyl group attached to one of the carbon atoms.

Explanation

The sum of the atomic weights of all the atoms in TAPP gives a molecular weight of 284.35 grams per mole.

Explanation

TAPP is used in research and pharmaceutical development as a molecular probe to study the function of certain receptors and transporters in the brain.

Explanation

TAPP possesses potential therapeutic properties for the treatment of conditions such as depression and Alzheimer's disease, although further research is needed to confirm these effects.

Structure

Piperidine ring with substituents

Substituents

tert-Butyl, methyl, cyanomethyl groups

Carboxylate groups

Two

Molecular weight

284.35 g/mol

Application

Molecular probe

Therapeutic potential

Depression and Alzheimer's disease

Upstream product

• 498-94-2 isonipecotic acid 
• 2971-79-1 isonipecotic acid methyl ester 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 268550-48-7 1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 546086-95-7 2,8-diazaspiro[4,5]decane-1-one 

Relevant articles and documents

INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL

Compounds of Formula I and the pharmaceutically acceptable salts thereof are provided as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.