135048-32-7

Basic information

• Product Name: 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI)
• Synonyms: 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI);2-Cyanoisonicotinohydrazide;4-Pyridinecarboxylicacid,2-cyano-,hydrazide;2-Cyano-4-pyridinecarboxylic acid hydrazide;Topiroxostat impurity M
• CAS NO: 135048-32-7
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.15
• Product Categories: AMIDE
• Mol File: 135048-32-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 10.38±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI)(135048-32-7)
• EPA Substance Registry System: 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI)(135048-32-7)

Safety Data

• Hazardous Substances Data: 135048-32-7(Hazardous Substances Data)

Usage

General Description

4-Pyridinecarboxylic acid, 2-cyano-, hydrazide (9CI) is a chemical compound with the molecular formula C7H6N4O. It is mainly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. 4-Pyridinecarboxylicacid,2-cyano-,hydrazide(9CI) is a white crystalline solid that is soluble in polar organic solvents. It has several potential applications in the fields of medicine and biochemistry due to its ability to act as a building block for the synthesis of heterocyclic compounds. Additionally, it has been studied for its antimicrobial and antioxidant properties. However, further research is required to fully understand the potential applications and mechanisms of action of this compound.

Upstream product

• 94413-64-6 2-Cyano-4-carbomethoxypyridine 
• 161233-97-2 2-cyanopyridine-4-carboxylic acid 
• 3783-38-8 methyl isonicotinate N-oxide 
• 58481-14-4 2-cyano-isonicotinic acid ethyl ester 

Relevant articles and documents

Preparation method of medicine for treating chronic hyperuricemia

The invention discloses a preparation method of a medicine for treating chronic hyperuricemia. The method comprises the following steps: using methyl 2-cyanoisonicotinate and 4-cyanopyridine as initial raw materials, and carrying out hydrazinolysis reaction, condensation reaction, cyclization reaction and purification to obtain topiroxostat. On one hand, by using a hydrochloric acid alcohol solution, the energy consumption of the process is reduced, and the problem of poor safety is improved; and on the other hand, topiroxostat hydrochloride is refined and concentrated in alcohol water and then subjected to a salt dissolving process, so that the solubility of the topiroxostat in an alkaline solution is increased, the problem that chloride exceeds the standard is preliminarily solved, the salt dissolving process is more thorough, and the reaction proceeding degree is increased. Finally, in the purification process, the amount of chlorides in the product is further reduced by a method of hot melting the crude product in alcohol water, and the product quality is ensured; and the purity of the product is improved by selecting a purification solvent.

Preparation method of topiroxostat

The invention provides a preparation method of topiroxostat. The preparation method comprises the steps that 2-cyano methyl isonicotinate is used as raw materials; hydrazinolysis is performed at -10 DEG C to -20 DEG C to obtain an intermediate; the intermediate and 4-cyanopyridine react under the conditions with sodium ethoxide and the pH being 4 to 6 to obtain the topiroxostat. The preparation method has the advantages that the 2-cyano methyl isonicotinate is used as a starting material; the 2-cyano methyl isonicotinate and hydrazine hydrate take condensation reaction at low temperature to prepare the intermediate; the intermediate and the 4-cyanopyridine are subjected to condensation and loop closing under the acid condition with sodium ethoxide to prepare the topiroxostat. The raw materials can be easily obtained; the reaction conditions are mild and are easy to control; a reagent with high toxicity is not used in the reaction process; the released toxic substances are few; the sidereaction products are few; the reaction safety is high; the pollution is small; the obtained purity is high; the preparation method is suitable for industrial production.

4 - [5 - (pyridin-4-yl) - 1H-[ 1, 2, 4] triazol-3-yl] pyridine-2-carbonitrile method for the preparation of (by machine translation)

The invention relates to a preparation of 4-[5-(pyridine-4-yl)-1H-[1,2,4]triazole-3-yl]pyridine-2-formonitrile. The method includes following steps: preparing a compound methyl 2-cyanoisonicotinate represented as the formula (4) with a compound methylisonicotinic-N-oxide (5) being a starting raw material in the presence of a copper catalyst (CuX), a metal cyanide and dimethylcarbamyl chloride; performing hydrazinolysis to the methyl 2-cyanoisonicotinate to obtain a compound 2-cyanoisoniazide represented as the formula (3); and finally performing condensation with a compound 4-cyanopyridine represented as the formula (2) to obtain a compound topiroxostat represented as the formula (1). The method only comprises three steps and is simple in operation and post-treatment. By means of the copper catalyst, a usage amount of the metal cyanide is greatly reduced so that reaction conditions are milder. The method is high in purity of the prepared product and is suitable for industrial production.