1351161-97-1Relevant articles and documents
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup
Stellwagen, John C.,Adjabeng, George M.,Arnone, Marc R.,Dickerson, Scott H.,Han, Chao,Hornberger, Keith R.,King, Alastair J.,Mook Jr., Robert A.,Petrov, Kimberly G.,Rheault, Tara R.,Rominger, Cynthia M.,Rossanese, Olivia W.,Smitheman, Kimberly N.,Waterson, Alex G.,Uehling, David E.
, p. 4436 - 4440 (2011/09/12)
A potent series of inhibitors against the B-RafV600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in rats. The key structural features of the series are an arylsulfonamide headgroup, a thiazole core, and a fluorine ortho to the sulfonamide nitrogen. Crown Copyright
