135206-76-7

Basic information

• Product Name: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE
• Synonyms: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE;3-(Chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride
• CAS NO: 135206-76-7
• Molecular Formula: C₄H₆ClN₃*ClH
• Molecular Weight: 131.56
• Mol File: 135206-76-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 255.3 °C at 760 mmHg
• Flash Point: 108.2 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 0.0164mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE(135206-76-7)
• EPA Substance Registry System: 3-CHLOROMETHYL-1-METHYL-1H-[1,2,4]TRIAZOLE(135206-76-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 135206-76-7(Hazardous Substances Data)

Usage

Uses

3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride is a useful research chemical.

InChI:InChI=1/C4H6ClN3/c1-8-3-6-4(2-5)7-8/h3H,2H2,1H3

Upstream product

• 91616-36-3 1-methyl-1H-[1,2,4]-(triazol-5-yl)methanol 
• 135242-93-2 (1-methyl-1H-[1,2,4]-triazol-3-yl)methanol 

Downstream Products

• 783331-24-8 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine 
• 497850-26-7 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 497850-19-8 7-{4-[2-(butoxy)ethoxy]phenyl}-1-isobutyl-N-({4-[(1-methyl-1H-1,2,4-triazol-5-yl)methyl]sulfanyl}phenyl)-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 731817-71-3 2-{8-fluoro-3-[4-fluoro-3-(1-methyl-1H-[1,2,4]triazol-3-ylmethoxy)phenyl]imidazo[1,2-c]pyrimidin-7-yl}propan-2-ol 
• 914654-33-4 Methyl 2-({3-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-2-phenylquinolin-4-yl}carbonyl)-1-phenylhydrazinecarboxylate 
• 73278-54-3 1-methyl-N5-[3-[3-(1-piperidinyl-methyl)phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine 
• 233276-07-8 3-(2-fluorophenyl)-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-7-(3-oxocyclobutyl)-1,2,4-triazolo[4,3-b]pyridazine 
• 265643-64-9 7-(2-fluorophenyl)-3-iodo-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine 
• 327985-35-3 3,8-diphenyl-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)imidazo[1,2-d][1,2,4]triazine 
• 327985-56-8 3-cyclohexyl-8-(2-fluorophenyl)-5-methyl-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)imidazo[1,2-d][1,2,4]triazine 
• 252750-22-4 5-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,3-triazolo[4,5-c]isoquinoline 
• 252750-10-0 6-(1,1-dimethylethyl)-5-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,3-triazolo[4,5-b]pyridine 
• 265643-68-3 5-hydroxymethyl-3-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-4-phenylpyrazole 
• 327985-57-9 3,8-bis(2-fluorophenyl)-5-methyl-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)imidazo[1,2-d][1,2,4]triazine 

Relevant articles and documents

DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS

Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H- imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

Optically active antifungal azoles. III. Synthesis and antifungal activity of sulfide and sulfonamide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3- mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

In an effort to find potent antifungal agents, optically active sulfur- containing triazole derivatives, sulfides (3) and sulfonamides (4), were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo. The sulfides (3) were prepared by the reaction of (2R,3R)- 2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1) with various heteroarylmethyl chlorides in the presence of sodium methoxide. The sulfonamides (4) were synthesized starting from the disulfide (15) in three steps including oxidation of the corresponding sulfenamides (17). Some of the sulfur-containing triazole derivatives (3, 4) showed strong protective effects against candidosis in mice.

Substituted alkanediphosphonic acids and pharmaceutical use

Alkanediphosphonic acids, in particular heteroarylalkanediphosphonic acids of formula STR1 wherein R1 is a 5-membered heteroaryl radical which may be fused with benzene or cyclohexene nuclei and which contains, as hetero atoms, 2 to 4 N-atoms or 1 or 2 N-atoms as well as 1 O- or S-atom, and which is unsubstituted or C-substituted by lower alkyl, phenyl or phenyl which is substituted by lower alkyl, lower alkoxy and/or halogen, or by lower alkoxy, hydroxy, di-lower alkylamino, lower alkylthio and/or halogen, and/or is N-substituted at a N-atom which is capable of substitution by lower alkyl, lower alkoxy and/or halogen, and R2 is hydrogen, hydroxy, amino, lower alkylthio or halogen, and salts thereof, have regulatory action on calcium metabolism and can be used as medicaments for the treatment of diseases associated with impairment of calcium metabolism. The compounds are obtained for example by converting, in a compound of formula STR2 wherein X1 is a functionally modified phosphono group and X2 is a free or functionally modified phosphono group, X1 and, if appropriate X2, into the free phosphono group.