1352621-99-8

Basic information

• Product Name: 1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester
• Synonyms: 1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester
• CAS NO: 1352621-99-8
• Molecular Weight: 489.602
• Mol File: 1352621-99-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester(1352621-99-8)
• EPA Substance Registry System: 1-bromo-2-(3-methoxyphenylamino)ethanesulfonic acid 2,4,6-trichlorophenyl ester(1352621-99-8)

Safety Data

• Hazardous Substances Data: 1352621-99-8(Hazardous Substances Data)

Upstream product

• 88-06-2 2,4,6-Trichlorophenol 
• 4790-35-6 ethenesulfonic acid 2,4,6-trichlorophenyl ester 
• 1352621-86-3 2,4,6-trichlorophenyl 1-bromoethenesulfonate 
• 536-90-3 m-Anisidine 

Downstream Products

• 1352622-07-1 2,4,6-trichlorophenyl 1-bromo-2-((3-methoxyphenyl)(methyl)amino)ethanesulfonate 
• 1968-17-8 6-methoxy-1-methyl-1H-indole 
• 7556-35-6 4-methoxy-1-methyl-1H-indole 
• 1352622-16-2 C₁₆H₁₆Cl₃NO₄S 

Relevant articles and documents

A selective, tin-free radical mediated synthesis of indoles based on a sulfonate template

A synthesis of indoles based on a vinyl sulfonate template is described. The approach employs a sulfonate group which plays three discrete roles in the synthetic sequence. Firstly the highly electron-withdrawing sulfonate group behaves as an activating group for a 1,4-addition of an aniline to the unsaturated system. Secondly, the electron-withdrawing nature of the same group also allows it to behave as a radical stabilising group which facilitates radical cyclisation to an aromatic ring to yield a transient indoline. Finally, the pendant sulfonate group behaves as a leaving group to yield the indole.