1352630-34-2

Basic information

• Product Name: 5-acetyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonitrile
• Synonyms: 5-acetyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonitrile
• CAS NO: 1352630-34-2
• Molecular Weight: 238.246
• Mol File: 1352630-34-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-acetyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonitrile(1352630-34-2)
• EPA Substance Registry System: 5-acetyl-6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonitrile(1352630-34-2)

Safety Data

• Hazardous Substances Data: 1352630-34-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 154867-20-6 3-phenylamino-2-[(phenylimino)methyl]acrylonitrile 
• 5394-63-8 2,2,6-trimethyl-4H-1,3-dioxin-4-one 
• 1352630-27-3 2-formyl-3-(phenylamino)acrylonitrile 

Relevant articles and documents

Synthesis of Pyridin-2(1H)-one derivatives: Temperature-dependent selectivity

Two alternative methods for the synthesis of biologically important pyridin-2(1H)-one derivatives have been developed. The behavior of enamine 1 with aromatic amines in an aqueous solution of HCl resulted in the formation of substituted enamines 2a-f at ambient temperature. The obtained product enamines 2a-f, upon treatment with 2,2,6-trimethyl-4H-1,3-dioxin-4-one, generated pyridin-2(1H)-one derivatives 5a-f along with the unwanted side products 8a-f. However, the exclusive formation of pyridin-2(1H)-one derivatives 5a-f was achieved when starting from β-enaminones 3a-f, which were synthesized successfully from enamine 1 and aromatic amines at elevated temperatures. Compounds 2 and 3 have been used as precursors in the synthesis of pyridin-2(1H)-one derivatives. Temperature-dependent reaction diversity was observed for enamine 1 and the exclusive formation of pyridin-2(1H)-one derivatives 5 was possible.