135334-14-4

Basic information

• Product Name: Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate
• Synonyms: Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate;Ethyl-2,2-difluoro-2-(3-chlorophenyl)-acetate
• CAS NO: 135334-14-4
• Molecular Formula: C₁₀H₉ClF₂O₂
• Molecular Weight: 234.6270664
• Mol File: 135334-14-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate(135334-14-4)
• EPA Substance Registry System: Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate(135334-14-4)

Safety Data

• Hazardous Substances Data: 135334-14-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate is a chemical compound with the molecular formula C10H9ClF2O2. It is a colorless liquid with a sweet, fruity odor and is commonly used as an intermediate in organic synthesis. Ethyl 2-(3-chlorophenyl)-2,2-difluoroacetate is an ester, meaning it is derived from an organic acid and an alcohol, and it is often used in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It has a wide range of potential applications in the field of industrial chemistry, including as a building block for the synthesis of various compounds with important biological activities. However, it is important to handle this compound with care, as it is classified as a hazardous material and should be used in a well-ventilated environment while wearing appropriate protective equipment.

Upstream product

• 625-99-0 3-iodochlorobenzene 
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Downstream Products

• 780769-50-8 2-(3-chlorophenyl)-2,2-difluoroethylamine 
• 780769-48-4 2-(3-chlorophenyl)-2,2-difluoroacetamide 

Relevant articles and documents

Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenyl ethan-1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.

Palladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides

A palladium-catalyzed Negishi cross-coupling reaction of ethyl bromodifluoroacetate with aryl bromides or aryl triflates to construct C(sp2)-CF2 bonds is described. The reaction was conducted under mild reaction conditions, and no preparation of organozinc reagents is required. This is the first report encompassing the conversion of aryl triflates into products containing C-CF2 bonds. In addition, the construction of C(sp2)-CHF bonds was achieved under mild conditions via a cross-coupling of aryl iodides with ethyl bromofluoroacetate.

Substituted phenyl acetamides and their use as protease inhibitors

Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compound