1354359-53-7

Basic information

• Product Name: JW 480
• Synonyms: 2-Isopropylphenyl (2-(naphthalen-2-yl)ethyl)carbamate;Cancer Hydrolase KIAA1363 Inhibitor, JW480;JW 480;PCNJGBMWAZRVEA-UHFFFAOYSA-N
• CAS NO: 1354359-53-7
• Molecular Formula: C₂₂H₂₃NO₂
• Molecular Weight: 333.42352
• Mol File: 1354359-53-7.mol
• Article Data: 1

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble20mg/mL, clear
• CAS DataBase Reference: JW 480(CAS DataBase Reference)
• NIST Chemistry Reference: JW 480(1354359-53-7)
• EPA Substance Registry System: JW 480(1354359-53-7)

Safety Data

• Hazard Codes: T,N
• Statements: 25-50/53
• Safety Statements: 45-60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 1354359-53-7(Hazardous Substances Data)

Usage

Uses

JW 480 is a selective and potent inhibitor of KIAA1363, a serine hydrolase enzyme.

Upstream product

• 2017-68-7 2-(naphthalen-2-yl)ethanamine 
• 1374130-39-8 2-isopropylphenyl (4-nitrophenyl) carbonate 
• 88-69-7 2-(1-methylethyl)phenol 

Relevant articles and documents

ANTI-CANCER SERINE HYDROLASE INHIBITORY CARBAMATES

Serine hydrolases are implicated in malconditions such as cancer, central nervous system disorders, cardiovascular disorders, obesity, and metabolic disorders. Many serine hydrolases expressed in proteomic libraries are of unknown function in vivo. Compounds identified through library versus library screening can be used for treatment of malconditions associated with the specific serine hydrolase KIAA1363 (also known as AADACL1). A library of inhibitors of KIAA1363 was prepared and candidate compounds were identified as a potent inhibitors having submicromolar IC50 values. An exemplary compound of the invention was shown to be an effective inhibitor of prostate cancer pathogenesis. Other inhibitory compounds of the invention comprising fluorophore groups are shown to be effective in spatial and temporal localization of the serine hydrolase in cells and tissues.