135508-69-9

Basic information

• Product Name: (6R,7R)-8-Oxo-3-pentafluorophenyloxycarbonyloxymethyl-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS NO: 135508-69-9
• Molecular Weight: 730.69
• Mol File: 135508-69-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (6R,7R)-8-Oxo-3-pentafluorophenyloxycarbonyloxymethyl-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-8-Oxo-3-pentafluorophenyloxycarbonyloxymethyl-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(135508-69-9)
• EPA Substance Registry System: (6R,7R)-8-Oxo-3-pentafluorophenyloxycarbonyloxymethyl-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(135508-69-9)

Safety Data

• Hazardous Substances Data: 135508-69-9(Hazardous Substances Data)

Upstream product

• 36919-02-5 pentafluorophenyl chloroformate 
• 29126-13-4 3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 
• 908093-98-1 diazodiphenylmethane 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 5935-65-9 Desacetylcephalothin 
• 75-44-5 phosgene 

Downstream Products

• 135508-70-2 (6R,7R)-3-{[Bis-(2-hydroxy-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-71-3 (6R,7R)-3-{[Bis-(2-hydroxy-propyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-77-9 (6R,7R)-3-{4-[Bis-(2-chloro-ethyl)-amino]-phenylcarbamoyloxymethyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-76-8 (6R,7R)-3-{[Bis-(2-bromo-propyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-75-7 (6R,7R)-3-{[Bis-(2-chloro-propyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-74-6 (6R,7R)-3-{[Bis-(2-bromo-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-73-5 (6R,7R)-3-{[Bis-(2-chloro-ethyl)-carbamoyloxy]-methyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135508-72-4 (6R,7R)-3-{4-[Bis-(2-hydroxy-ethyl)-amino]-phenylcarbamoyloxymethyl}-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

Synthesis of beta-lactamase activated nitric oxide donors

In order to achieve site specific delivery of NO, we designed conjugates of cephalosporin with NO donors. NO donors such as cupferron and SIN-1 were evaluated as potential choices for conjugates. Cephalosporin conjugated with SIN-1 demonstrated promising beta-lactamase dependent NO releasing ability.