1356175-81-9

Basic information

• Product Name: (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one
• CAS NO: 1356175-81-9
• Molecular Weight: 207.232
• Mol File: 1356175-81-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one(1356175-81-9)
• EPA Substance Registry System: (3Z)-3-{1-[(5-methyl-1H-pyrazol-3-yl)amino]ethylidene}-4,5-dihydrofuran-2(3H)-one(1356175-81-9)

Safety Data

• Hazardous Substances Data: 1356175-81-9(Hazardous Substances Data)

Upstream product

• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 31230-17-8 3-amino-5-methylpyrazole 

Relevant articles and documents

Regioselective synthesis of fused pyrazolo[1,5-a]pyrimidines by reaction of 5-amino-1H-pyrazoles and β-dicarbonyl compounds containing five-membered rings

Reactions of 3-substituted-5-amino-1H-pyrazoles with 2-acetylcyclopentanone or 2-ethoxycarbo-nylcyclopentanone lead to the regioselective formation of a new series of cyclopentapyrazolo[1,5-a]pyrimidines in good yields. When 2-acetylbutyrolactone was used, the reaction provided 6-(2-hydroxyethyl) pyrazolo[1,5-a]pyrimidinone and/or the intermediate (3Z)-3-{1-[(5-R-1H-pyrazol- 3-yl)amino]ethylidene}-4,5-dihydrofuranone. This indicates that the cyclization proceeds with butyrolactone ring opening as the last step. Several aspects of this regioselective reaction, including mechanistic and structural studies, are considered.