135664-20-9Relevant articles and documents
Charge-Transfer Complex Promoted C-N Bond Activation for Ni-Catalyzed Carbonylation
Yu, Hui,Gao, Bao,Hu, Bin,Huang, Hanmin
supporting information, p. 3520 - 3523 (2017/07/17)
A new strategy was developed for activation of C-N bond via formation of an amine-I2 charge-transfer complex, which facilitates the inert C-N bond activation via oxidative addition with Ni(0). This strategy has been successfully applied in the Ni-catalyzed carbonylation of benzylamines via direct insertion of CO into the C-N bond, which provided a straightforward and rapid approach to arylacetamides in the presence of catalytic amounts of I2 and Ni catalyst. Mechanistic studies suggested that a benzyl radical generated via the oxidative addition was involved in the present reaction.
Investigations into the enantioselective C-protonation of prostereogenic enolate(s) derived from N,N′-diisopropyl-2-phenylpropanamide using suicide C-based proton sources
Coumbarides, Gregory S.,Eames, Jason,Ghilagaber, Stephanos,Suggate, Michael J.
, p. 9469 - 9474 (2007/10/03)
The synthesis of enantiomerically enriched (-)-(R)-N, N′-diisopropyl- 2-phenylpropanamide was achieved in up to 69% enantiomeric excess by symmetrisation of the corresponding racemic amide by addition of sec-BuLi (to give the corresponding achiral lithium
