1356963-00-2

Basic information

• Product Name: 1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one
• Synonyms: 1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one
• CAS NO: 1356963-00-2
• Molecular Weight: 264.281
• Mol File: 1356963-00-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one(1356963-00-2)
• EPA Substance Registry System: 1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-one(1356963-00-2)

Safety Data

• Hazardous Substances Data: 1356963-00-2(Hazardous Substances Data)

Upstream product

• 177-11-7 4,4-ethylenedioxy-piperidine 
• 83341-28-0 5-fluoro-4-methyl-2-nitrophenol 
• 452-78-8 3-fluoro-4-methyl phenol 
• 1356962-93-0 8-(5-Methoxy-2-methyl-4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 314298-13-0 1-fluoro-5-methoxy-2-methyl-4-nitro-benzene 
• 106579-00-4 5-methoxy-2-methyl-4-nitroaniline 

Downstream Products

• 1356962-99-6 (R)-4-(3-fluoropyrrolidin-1-yl)-1-(5-methoxy-2-methyl-4-nitrophenyl)piperidine 
• 1356962-90-7 1-(1-(5-methoxy-2-methyl-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine 

Relevant articles and documents

DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE

Disclosed herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation, and methods of preparation and uses thereof.

CHEMICAL COMPOUNDS

The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK kinase activity, and thus may be used for the tr