135711-18-1 Usage
Description
(R)-(-)-2-(2-ISOINDOLINYL)BUTAN-1-OL, also known as (βR)-β-Ethyl-1,3-dihydro-2H-isoindole-2-ethanol, is a chiral reagent derived from the isoindoline family of compounds. It is characterized by its beige crystalline appearance and is known for its unique chemical properties that make it a valuable component in various organic syntheses.
Uses
Used in Pharmaceutical Industry:
(R)-(-)-2-(2-ISOINDOLINYL)BUTAN-1-OL is used as a chiral reagent for the synthesis of various pharmaceutical compounds. Its unique stereochemistry allows for the creation of enantiomerically pure drugs, which is crucial in the development of more effective and safer medications.
Used in Chemical Synthesis:
In the field of chemical synthesis, (R)-(-)-2-(2-ISOINDOLINYL)BUTAN-1-OL serves as a key intermediate in the production of various organic compounds. Its versatility in reacting with different reagents makes it a valuable asset in the synthesis of complex molecules.
Used in Research and Development:
(R)-(-)-2-(2-ISOINDOLINYL)BUTAN-1-OL is also utilized in research and development for the exploration of new chemical reactions and the discovery of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Used in Analytical Chemistry:
The compound's chiral nature makes it an essential tool in analytical chemistry for the separation and analysis of enantiomers. This is particularly important in the quality control and purity assessment of chiral drugs and other biologically active molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 135711-18-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,7,1 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 135711-18:
(8*1)+(7*3)+(6*5)+(5*7)+(4*1)+(3*1)+(2*1)+(1*8)=111
111 % 10 = 1
So 135711-18-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO/c1-2-12(9-14)13-7-10-5-3-4-6-11(10)8-13/h3-6,12,14H,2,7-9H2,1H3/p+1/t12-/m1/s1
135711-18-1Relevant articles and documents
Synthesis and in vitro antimycobacterial activity of compounds derived from (R)- and (S)-2-amino-1-butanol - The crucial role of the configuration
Dobrikov, Georgi M.,Valcheva, Violeta,Stoilova-Disheva, Margarita,Momekov, Georgi,Tzvetkova, Pavleta,Chimov, Angel,Dimitrov, Vladimir
supporting information; experimental part, p. 45 - 56 (2012/03/26)
The synthesis of 47 structurally diverse compounds incorporating the (R)-2-amino-1-butanol motif has been realized. Ten of these compounds were found to exhibit in vitro specific activity against Mycobacterium tuberculosis H37Rv in a MIC range of 0.65 μM-14.03 μM. Five of the most active compounds 11, 22, 23, 31 and 42 (5.7-11.1 fold more active than ethambutol) can be outlined with very low cytotoxicity towards human embryonal kidney non-tumour cells (SI ranging from 91.2 to 375.4). For the purpose of comparison the (S)-enantiomers of these most active compounds have been synthesized and evaluated towards M. tuberculosis H37Rv showing no activity even at 20-32 fold higher concentrations.
Determination of the Enantiomeric Excesses of Chiral Acids by 19F NMR Studies of their Esters deriving from (R)-(+)-2-(Trifluoromethyl)benzhydrol
Brown, Eric,Chevalier, Christelle,Huet, Francois,Grumelec, Christelle Le,Leze, Antoine,Touet, Joel
, p. 1191 - 1194 (2007/10/02)
15-Chiral acids were esterified with optically pure (R)-(+)-2-(trifluoromethyl)benzhydrol (R)-(+)-1, a readily available reagent.With respect to the carboxy group, the stereogenic centre is in the β-position in the case of the acids 5a-10a and 12a-16a, and in the α position in the case of the acids 17a-20a.The diastereomeric excesses of the corresponding esters 5b-10b and 12b-20b, respectively, were easily determined by means of 19F NMR.These d.e. values were in very good agreement with the e.e. values of the corresponding acids when the latter were known compounds.
