1357389-11-7 Usage
Description
RGFP-966, also known as (E)-RGFP 966, is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 of 80 nM. It has demonstrated the ability to facilitate the extinction of cocaine-seeking behavior in mice and enhance the transformation of subthreshold learning events into robust long-term memory. These properties suggest that RGFP-966 has potential therapeutic applications in memory enhancement and the treatment of neurodegenerative diseases.
Uses
Used in Pharmaceutical Industry:
RGFP-966 is used as a histone deacetylase 3 (HDAC3) inhibitor for its potential therapeutic effects on memory enhancement and neurodegenerative diseases. Its ability to facilitate the extinction of cocaine-seeking behavior in mice and transform subthreshold learning events into robust long-term memory indicates its potential as a promising candidate for the development of treatments targeting memory-related conditions and neurodegenerative disorders.
Used in Research Applications:
RGFP-966 is used as a research tool for studying the role of HDAC3 in various biological processes, including memory formation and neurodegenerative diseases. Its selectivity for HDAC3 allows researchers to investigate the specific functions and pathways regulated by this enzyme, contributing to a better understanding of the underlying mechanisms and potential therapeutic targets for related conditions.
References
1) Malvaez?et al.?(2013),?HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA?110?2647
2) Bieszczad?et al.?(2015),?Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci.?35?13124
3) Zhu?et al.?(2017),?HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell?16?1073
4) Haiqun?et al. (2016),?The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498
5) Janczura?et al.?(2018),?Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA?115?E11148
Check Digit Verification of cas no
The CAS Registry Mumber 1357389-11-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,7,3,8 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1357389-11:
(9*1)+(8*3)+(7*5)+(6*7)+(5*3)+(4*8)+(3*9)+(2*1)+(1*1)=187
187 % 10 = 7
So 1357389-11-7 is a valid CAS Registry Number.