135969-53-8

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, (2Z)-2-butenedioate (1:1)
• Synonyms: S (-) amlodipine maleate;(S)-amiodipine maleate;(S)-amlodipine maleate;(-)-amlodipine maleate;compound with (Z)-but-2-enedioic acid;(S)-3-ethyl-5-methyl-2-(2-aminoethoxymethyl)-4-(2-cholorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate maleate;S(-) amlodipine maleate;(S)-2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
• CAS NO: 135969-53-8
• Molecular Formula: C20H25ClN2O5.C4H4O4
• Molecular Weight: 524.94800
• Mol File: 135969-53-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, (2Z)-2-butenedioate (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, (2Z)-2-butenedioate (1:1)(135969-53-8)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-, (2Z)-2-butenedioate (1:1)(135969-53-8)

Safety Data

• Hazardous Substances Data: 135969-53-8(Hazardous Substances Data)

Upstream product

• 103129-82-4 amlodipine 
• 110-16-7 maleic acid 

Relevant articles and documents

CRYSTALLINE S-(-)-AMLODIPINE MALEIC ACID SALT ANHYDRIDE AND PREPARATION METHOD THEREOF

Disclosed are an anhydrate of crystalline S-(-)-amlodipine maleate and a preparation method thereof. The anhydrate of crystalline S-(-)-amlodipine maleate exhibits excellent physical and chemical properties including non-hygroscopicity, solubility, therma

A process for the preparation of s (-) amlodipine salts

Described herein is a process for the preparation of S(-)Amlodipine salts which comprises reaction of S(-)Amlodipine base with a solution of pharmaceutically acceptable acid such as benzene sulfonic acid, oxalic acid, maleic acid, succinic acid and p-toluene sulfonic acid. The reaction is carried out in the presence of an organic solvent at room temperature. The organic solvents include alcohols like ethanol, methanol, 2-propanol, hydrocarbons like toluene and polar solvents like dimethyl sulfoxide. The salt is obtained by addition of water and isolation of the salt formed by filtration. The unique feature of the invention is production of S(-) Amlodipine besylate in good chemical yield, high enantiomeric purity and with the quality required for preparation of pharmaceutical composition i.e. tablet formulation.