1361504-77-9 Usage
Description
DG172 (dihydrochloride) is an orally available inverse agonist of PPARβ/δ, characterized by its potent activity in inhibiting the transcription of the ANGPTL4 gene in mouse myoblasts. It plays a significant role in altering the differentiation of bone marrow cells and has been shown to inhibit cancer cell invasion through the suppression of ANGPTL4 expression.
Uses
Used in Pharmaceutical Industry:
DG172 (dihydrochloride) is used as a therapeutic agent for its ability to inhibit cancer cell invasion. The compound functions by suppressing the expression of the ANGPTL4 gene, which is associated with cancer cell invasion and metastasis.
Used in Research Applications:
DG172 (dihydrochloride) is used as a research tool for studying the role of PPARβ/δ in various cellular processes. It is particularly valuable in investigating the differentiation of bone marrow cells and the development of dendritic cell subsets, as well as the regulation of ANGPTL4 gene expression in mouse myoblasts.
Used in Drug Development:
DG172 (dihydrochloride) is used as a lead compound in the development of new drugs targeting PPARβ/δ. Its inverse agonist activity makes it a promising candidate for the treatment of conditions related to the dysregulation of this receptor, such as cancer and other diseases involving cell differentiation and gene expression.
references
[1]. lieber s, scheer f, meissner w, et al. (z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (dg172): an orally bioavailable pparβ/δ-selective ligand with inverse agonistic properties. j med chem. 2012 mar 22;55(6):2858-68.[2]. lieber s, scheer f, finkernagel f, et al. the inverse agonist dg172 triggers a pparβ/δ-independent myeloid lineage shift and promotes gm-csf/il-4-induced dendritic cell differentiation. mol pharmacol. 2015 feb;87(2):162-73.[3]. adhikary t, brandt dt, kaddatz k, et al. inverse pparβ/δ agonists suppress oncogenic signaling to the angptl4 gene and inhibit cancer cell invasion. oncogene. 2013 oct 31;32(44):5241-52.
Check Digit Verification of cas no
The CAS Registry Mumber 1361504-77-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,5,0 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1361504-77:
(9*1)+(8*3)+(7*6)+(6*1)+(5*5)+(4*0)+(3*4)+(2*7)+(1*7)=139
139 % 10 = 9
So 1361504-77-9 is a valid CAS Registry Number.
1361504-77-9Relevant articles and documents
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): An orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties
Lieber, Sonja,Scheer, Frithjof,Meissner, Wolfgang,Naruhn, Simone,Adhikary, Till,Müller-Brüsselbach, Sabine,Diederich, Wibke E.,Müller, Rolf
experimental part, p. 2858 - 2868 (2012/06/15)
The ligand-regulated nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a potential pharmacological target due to its role in disease-related biological processes. We used TR-FRET-based competitive ligand binding and coregulator
