136160-18-4

Basic information

• Product Name: 5-methyl-6-(phenylsulfanyl)pyrimidine-2,4(1H,3H)-dione
• Synonyms: 2,4-pyrimidinediol, 5-methyl-6-(phenylthio)-; 5-methyl-6-(phenylsulfanyl)pyrimidine-2,4-diol; 6-(Phenylthio)thymine
• CAS NO: 136160-18-4
• Molecular Formula: C₁₁H₁₀N₂O₂S
• Molecular Weight: 234.2743
• Mol File: 136160-18-4.mol
• Article Data: 5

Chemical Properties

• Density: 1.37g/cm³
• Refractive Index: 1.66
• CAS DataBase Reference: 5-methyl-6-(phenylsulfanyl)pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-6-(phenylsulfanyl)pyrimidine-2,4(1H,3H)-dione(136160-18-4)
• EPA Substance Registry System: 5-methyl-6-(phenylsulfanyl)pyrimidine-2,4(1H,3H)-dione(136160-18-4)

Safety Data

• Hazardous Substances Data: 136160-18-4(Hazardous Substances Data)

Upstream product

• 31458-38-5 6-iodo-5-methylpyrimidine-2,4(1H,3H)-dione 
• 65-71-4 thymin 
• 136160-46-8 N₁-(methoxymethyl)thymine 
• 136160-17-3 1-(methoxymethyl)-6-phenylthiothymine 
• 1627-28-7 6-chloro-5-methylpyrimidine-2,4(1H,3H)-dione 
• 2417-22-3 5-methylbarbituric acid 
• 132774-43-7 1-<(benzyloxy)methyl>-6-(phenylthio)thymine 
• 123027-56-5 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine 

Downstream Products

• 136160-19-5 1-methyl-6-(phenylthio)thymine 
• 157401-07-5 5-Methyl-6-phenylsulfanyl-1-((E)-3-thiophen-2-yl-allyl)-1H-pyrimidine-2,4-dione 
• 157401-06-4 1-((E)-3-Furan-2-yl-allyl)-5-methyl-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 157401-05-3 5-Methyl-6-phenylsulfanyl-1-((E)-3-pyridin-3-yl-allyl)-1H-pyrimidine-2,4-dione 
• 136160-20-8 1-ethyl-6-(phenylthio)thymine 
• 157401-04-2 5-Methyl-1-((E)-3-phenyl-allyl)-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 136160-21-9 1-butyl-6-(phenylthio)thymine 
• 144410-28-6 dimethyl-6-(phenylthio)thymine 

Relevant articles and documents

Functionalization of unprotected uracil derivatives using the halogen - Magnesium exchange

The reaction of commercially available 5-iodouracil with 2 equiv of MeMgCl in the presence of LiCl, followed by the addition of i-PrMgCl-LiCl, provides the corresponding trimagnesiated species, which reacts with various electrophiles to give selectively 5

Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof

The disclosure concerns pyrimidine derivatives represented by the following general formulas [I] and [I'] and having antiviral activity, particularly antiretroviral activity such as anti-HIV activity: STR1 and pharmaceutical compositions having antiviral

Synthesis and Antiviral Activity of Deoxy Analogs of 1--6-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents

The effect of substitution in the acyclic structure of 1--6-(phenylthio)thymine (HEPT) on anti-HIV-1 activity was investigated by synthesizing a series of deoxy analogs and related compounds.Preparation of 1-(2-alkyloxyethoxy)met