1363380-59-9

Basic information

• Product Name: cis-4-AMinotetrahydropyran-3-ol
• Synonyms: cis-4-AMinotetrahydropyran-3-ol;(3R,4R)-rel-4-Aminotetrahydro-2H-pyran-3-ol
• CAS NO: 1363380-59-9
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.14634
• Mol File: 1363380-59-9.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cis-4-AMinotetrahydropyran-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4-AMinotetrahydropyran-3-ol(1363380-59-9)
• EPA Substance Registry System: cis-4-AMinotetrahydropyran-3-ol(1363380-59-9)

Safety Data

• Hazardous Substances Data: 1363380-59-9(Hazardous Substances Data)

Upstream product

• 78870-52-7 (1SR,6RS)-3,7-dioxa-bicyclo[4.1.0]heptane 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 134419-59-3 4-oxanyl methanesulfonate 
• 25637-16-5 4-bromotetrahydro-2H-pyran 
• 3174-74-1 dihydropyran 
• 286-22-6 3,4-epoxytetrahydropyran 
• 1268515-66-7 (3R,4S)-3-(benzyloxy)tetrahydro-2H-pyran-4-amine 
• 1268515-65-6 (3S)-3-(benzyloxy)-tetrahydro-4H-pyran-4-one 
• 1268515-64-5 (3S)-3-(benzylyoxy)-4,4-dimethoxytetrahydro-2H-pyran 
• 1034144-67-6 (3S)-4,4-dimethoxytetrahydro-2H-pyran-3-ol 
• 693245-80-6 4,4-dimethoxy-5,6-dihydro-2H-pyran-3(4H)-one 
• 104681-92-7 4,4-dimethoxytetrahydro-2H-pyran-3-ol 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 1351450-56-0 3-benzyloxytetrahydropyran-4-one 

Downstream Products

• 1096770-58-9 (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol 
• 1096594-11-4 3-amino-1,5-anhydro-2,3-dideoxy-L-threo-pentitol hydrochloride 
• 1630815-44-9 (3SR,4RS)-4-aminotetrahydro-2H-pyran-3-ol hydrochloride 

Relevant articles and documents

MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention relates to compounds of formula (I), or their isotopic forms, stereoisomers, tautomers or pharmaceutically acceptable salt (s) thereof as muscarinic M1 receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound formula (I).

BENZOISOQUINOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS

The present invention is directed to substituted benzoisoquinolinone compounds, their salts, pharmaceutical compositions comprising them and their use in therapy. In particular, the invention is directed substituted benzoisoquinolinone compounds which are muscarinic M1 receptor positive allosteric modulators. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M1 receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M1 receptors are involved.

FLOURO-NAPHTHYL DERIVATIVES

The present invention relates to compounds of formula wherein R1 is C4-6-cycloalkyl or C4-6-heterocycloalkyl, which are optionally substituted by one or two substituents, selected from hydroxy or lower alkyl; A is phenyl, pyridinyl or piperidinyl; R2 is hydrogen, halogen, lower alkyl, cyano, C4-6-cycloalkyl, lower alkoxy, lower alkoxy substituted by halogen, or is a five- or six-membered heteroaryl, optionally substituted by lower alkyl; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment or prophylaxis of Alzheimer's disease, cognitive impairment, schizophrenia, pain or sleep disorders.