13636-02-7

Basic information

• Product Name: 3-(Dimethylamino)-1-(2-thienyl)-1-propanol
• Synonyms: 3-(n,n-dimethylamino)-1-(2-thienyl)propan-1-ol;n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine;3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol;3-(Dimethylamino)-1-;3-(Dimetylamino)-1-(2-thienyl)-1-propanol;2-[3-(Dimethylamino)-1-hydroxypropyl]thiophene;3-(DiMethylaMino)-1-(2-Tienyl)-1-Popanol;3-DiMethylaMino-1-thiophen-3-yl-propan-1-ol
• CAS NO: 13636-02-7
• Molecular Formula: C₉H₁₅NOS
• Molecular Weight: 185.29
• EINECS: 226-202-0
• Product Categories: Heterocycle-oher series
• Mol File: 13636-02-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: 70.0 to 74.0 °C
• Boiling Point: 290°C
• Flash Point: 129°C
• Appearance: /
• Density: 1.111
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 13.74±0.20(Predicted)
• CAS DataBase Reference: 3-(Dimethylamino)-1-(2-thienyl)-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Dimethylamino)-1-(2-thienyl)-1-propanol(13636-02-7)
• EPA Substance Registry System: 3-(Dimethylamino)-1-(2-thienyl)-1-propanol(13636-02-7)

Safety Data

• Hazardous Substances Data: 13636-02-7(Hazardous Substances Data)

Usage

Uses

3-(Dimethylamino)-1-(2-thienyl)-1-propanol is useful for the preparation of chitosan compounds for optical isomer separating agents.

InChI:InChI=1/C9H15NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-4,7-8,11H,5-6H2,1-2H3

Upstream product

• 132335-49-0 α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol 
• 13196-35-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one 
• 34772-98-0 3-dimethylamino-1-thiophen-2-ylpropenone 
• 5424-47-5 3-(dimethylamino)-1-(thiophen-2-yl)propan-1-one hydrochloride 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 287737-72-8 (S)-N,N-dimethyl-N-[3-hydroxy-3-(2-thienyl)propyl]-ammonium (S)-mandelate 
• 132335-49-0 α-[2-(dimethylamino)ethyl](thiophene-2-yl)methanol 
• 132335-47-8 (S)-N,N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine oxalate 
• 136434-34-9 duloxetine hydrochloride 
• 132335-46-7 N-methyl-(S)-duloxetine 
• 947686-09-1 (S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine 
• 1369583-87-8 N-[4-(2-methoxyphenylpiperazinyl)propionyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-88-9 N-[4-(3-trifluoromethylphenylpiperazinyl)propionyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-90-3 N-[4-(4-(2-methoxyphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-91-4 N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-93-6 N-[4-(2-methoxyphenylpiperazinyl)propyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-94-7 N-[4-(3-trifluoromethylphenylpiperazinyl)propyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-96-9 N-[4-(4-(2-methoxyphenylpiperazinyl))butyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 
• 1369583-97-0 N-[4-(4-(3-trifluoromethylphenylpiperazinyl))butyl]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine 

Relevant articles and documents

Preparation method of S-(+)duloxetine hydrochloride intermediate

The invention discloses a preparation method of a compound of a formula B (shown in the description). The preparation method comprises the steps of dissolving a compound of a formula A (shown in the description) in a solvent, and reacting under the effect of a reducing agent. Furthermore, the ee value of the compound of the formula B obtained by reducing in the presence of a complex, namely ferrocene, is over 98%. The preparation method provided by the invention is simple and feasible, the resolution or the chiral catalysis induction is not required, the product yield and the chiral purity arehigh, and the preparation method is suitable for the industrial production of S-(+)duloxetine hydrochloride intermediate.

Preparation of duloxetine hydrochloride

The invention belongs to the fields of organic chemistry and pharmaceutical chemistry, and particularly relates to a synthesis technique of duloxetine hydrochloride. By converting the R configuration compound into S configuration, compared with the duloxetine hydrochloride prepared from the single S-configuration compound, the total yield is enhanced by nearly 47%, and the production cost is lowered. 1-chloroethylchloroformate is used instead of phenyl chloro-formate to directly generate the duloxetine hydrochloride during demethylation, thereby reducing the salification step, shortening the production cycle and saving the cost.

New amine compound and use thereof in treatment of depression

The invention relates to a new amine compound and a use thereof in the treatment of depression, and concretely relates to a compound represented by formula I, optical isomers, solvates or pharmaceutically acceptable salts thereof, and a use thereof in the preparation of antidepressant drugs. Preclinical pharmacological studies show that the compound is comparable to and even better than first-line antidepressants (such as duloxetine).