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136401-59-7

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136401-59-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 136401-59-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,4,0 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 136401-59:
(8*1)+(7*3)+(6*6)+(5*4)+(4*0)+(3*1)+(2*5)+(1*9)=107
107 % 10 = 7
So 136401-59-7 is a valid CAS Registry Number.

136401-59-7Downstream Products

136401-59-7Relevant articles and documents

Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds

Momose,Meguro,Ikeda,Hatanaka,Oi,Sohda

, p. 1440 - 1445 (2007/10/02)

Various analogues of a new antidiabetic agent, pioglitazone (AD-4833, U-72107), were synthesized in order to study in more detail the structure-activity relationships of this class of drug. 5-(4-Pyridylalkylthiobenzyl)-2,4-thiazolidinediones (I), this-analogues of pioglitazone, were prepared via Meerwein arylation of the alkylthioanilines (IV). 5-(4-Pyridylalkoxybenzylidene)-2,4-thiazolidinediones (IIa) and related heterocyclic analogues (IIb) were synthesized by Knoevenagel condensation of the aldehydes (VIII) with the corresponding azolidinones. Compounds I and II were evaluated for hypoglycemic and hypolipidemic activity in genetically obese and diabetic yellow KK (KKA(y)) mice. Several 5-[4-[2-(2-pyridyl)ethoxy]-benzylidene]-2,4-thiazolidinediones (IIa) were equipotent to pioglitazone. However, the thia-analogues (I) and the benzylideneheterocycles (IIb) had decreased activity. Catalytic hydrogenation of the 5-benzylidene analogue (14) was found to be a convenient new synthetic method for pioglitazone. The configuration of 14 is also discussed.

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