136401-96-2

Basic information

• Product Name: 4-(2-Pyridin-2-yl-ethoxy)-benzonitrile
• CAS NO: 136401-96-2
• Molecular Weight: 224.262
• Mol File: 136401-96-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-Pyridin-2-yl-ethoxy)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Pyridin-2-yl-ethoxy)-benzonitrile(136401-96-2)
• EPA Substance Registry System: 4-(2-Pyridin-2-yl-ethoxy)-benzonitrile(136401-96-2)

Safety Data

• Hazardous Substances Data: 136401-96-2(Hazardous Substances Data)

Upstream product

• 103-74-2 2-(2-Hydroxyethyl)pyridine 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 136401-63-3 5-(4-(2-(pyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione 
• 85259-45-6 4-<2-(2-pyridyl)ethoxy>benzaldehyde 

Relevant articles and documents

Studies on antidiabetic agents. X. Synthesis and biological activities of pioglitazone and related compounds

Various analogues of a new antidiabetic agent, pioglitazone (AD-4833, U-72107), were synthesized in order to study in more detail the structure-activity relationships of this class of drug. 5-(4-Pyridylalkylthiobenzyl)-2,4-thiazolidinediones (I), this-analogues of pioglitazone, were prepared via Meerwein arylation of the alkylthioanilines (IV). 5-(4-Pyridylalkoxybenzylidene)-2,4-thiazolidinediones (IIa) and related heterocyclic analogues (IIb) were synthesized by Knoevenagel condensation of the aldehydes (VIII) with the corresponding azolidinones. Compounds I and II were evaluated for hypoglycemic and hypolipidemic activity in genetically obese and diabetic yellow KK (KKA(y)) mice. Several 5-[4-[2-(2-pyridyl)ethoxy]-benzylidene]-2,4-thiazolidinediones (IIa) were equipotent to pioglitazone. However, the thia-analogues (I) and the benzylideneheterocycles (IIb) had decreased activity. Catalytic hydrogenation of the 5-benzylidene analogue (14) was found to be a convenient new synthetic method for pioglitazone. The configuration of 14 is also discussed.