136450-11-8Relevant articles and documents
Industrial preparation method of anti-asthma drug pranlukast intermediate
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Paragraph 0015-0020; 0022; 0024, (2020/04/17)
The invention discloses a preparation method of a pranlukast intermediate N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide (short for formula I), specifically a method for preparing N-(2-cyano-4-oxo-4H-chromene-8-yl)-4-(4-butoxyphenyl)benzamide by carrying out a dewatering reaction on 4-oxo-8-[4-(4-butoxyphenyl)benzamide]-4H-chromene-2-formamide (short for formula II). The preparation method of the pranlukast intermediate represented by the formula I is high in yield, good in product color, high in product purity and beneficial to industrial production.
A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists
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Page/Page column 7, (2010/11/30)
A process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR1 group, wherein R1 is C1-C6 alkyl or phenyl optionally substituted by a -O-(CH2)su
PROCESS FOR PRODUCING CHROMONE COMPOUND
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Page 24, 25, (2008/06/13)
A process for producing a dicarboxylic acid compound represented by the formula (4): wherein R1 and R2 are the same or different and each represents lower alkyl and the wavy line indicates that this compound is the E- or Z-isomer or