1365052-77-2

Basic information

• Product Name: C₂₁H₂₀BrClN₄O₂
• Synonyms: C₂₁H₂₀BrClN₄O₂
• CAS NO: 1365052-77-2
• Molecular Weight: 475.772
• Mol File: 1365052-77-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₀BrClN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₀BrClN₄O₂(1365052-77-2)
• EPA Substance Registry System: C₂₁H₂₀BrClN₄O₂(1365052-77-2)

Safety Data

• Hazardous Substances Data: 1365052-77-2(Hazardous Substances Data)

Upstream product

• 1365052-57-8 C₁₉H₁₇BrN₂O₂ 
• 1761-61-1 5-bromosalicyclaldehyde 
• 636992-53-5 1-(3-amino-5-bromo-benzofuran-2-yl)-ethanone 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 1365052-67-0 C₁₉H₁₉BrN₄O 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

Synthesis and antiinflammatory activity of 1H-pyrazolines bearing 5-bromo-3-amino benzofuran

5-Bromo-3-amino-2-acetyl banzofuran 3 was prepared by the interaction of 5-bromosalicylonitrile and chloroacetone in presence of anhyd potassium carbonate in dry acetone. The compound 3 was treated with different substituted aromatic aldehydes in ethanol in presence of strong alkali to give 5-bromo-3-amino-2-arylidene acetylbenzofurans (4a-e). 5-(3-Amino-5- bromobenzofuran)-3-aryl-2-pyrazolines (5ae) were synthesized by the reaction of 5-bromo-3-amino-2-arylidene acetylbenzofurans (4a-e) with hydrazine hydrate. The reaction of compounds (5a-e) with chloroacetyl chloride in presence of triethylamine in dry toluene furnished 5-aryl-3-[5'-bromo-3'-(chloroacetyl)- aminobenzofuran-2-yl]-1H-pyrazolines (6a-e). All synthesized compounds were screened for their antimicrobial activities and some selected benzofuran pyrazoline derivatives were screened for antiinflammatory activities.