136540-25-5

Basic information

• Product Name: 3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-2-methylisoquinolin-1(2H)-one
• CAS NO: 136540-25-5
• Molecular Formula: C₂₂H₂₅NO₆
• Molecular Weight: 399.437
• Mol File: 136540-25-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 622.2°C at 760 mmHg
• Flash Point: 330.1°C
• Density: 1.226g/cm³
• Vapor Pressure: 2.43E-16mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-2-methylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-2-methylisoquinolin-1(2H)-one(136540-25-5)
• EPA Substance Registry System: 3-[2-(2-hydroxyethyl)-4,5-dimethoxyphenyl]-6,7-dimethoxy-2-methylisoquinolin-1(2H)-one(136540-25-5)

Safety Data

• Hazardous Substances Data: 136540-25-5(Hazardous Substances Data)

Upstream product

• 144709-22-8 3-<2-(methoxycarbonyl-methyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-1(2H)-isoquinolone 
• 144709-21-7 [2-(6,7-Dimethoxy-1-oxo-1,2-dihydro-isoquinolin-3-yl)-4,5-dimethoxy-phenyl]-acetic acid 
• 144709-20-6 3,4-dimethoxy-6-iodobenzamide 
• 17173-27-2 methyl 2-(2-acetyl-4,5-dimethoxyphenyl)acetate 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 38210-84-3 2-acetyl-4,5-dimethoxyphenylacetic acid 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 173031-06-6 3-<2-(2-t-butyldiphenylsilyloxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-N-methyltetrahydroisoquinoline 
• 144709-24-0 N-methyl-3<2-(methoxycarbonylmethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-1(2H)-isoquinolone 
• 125455-89-2 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydroisoquinoline-1-one 

Downstream Products

• 136540-26-6 O-methylfagaronine iodide 
• 15462-10-9 2,3,8,9-tetramethoxybenzophenanthridine 
• 125455-89-2 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydroisoquinoline-1-one 
• 140169-37-5 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolone O-tosylate 
• 114253-63-3 O-methyl-6-oxofagaronine 
• 140169-36-4 3-<2-(2-hydroxyethyl)-4,5-dimethoxyphenyl>-6,7-dimethoxy-2-methylisoquinolone O-acetate 

Relevant articles and documents

Oxidation reactions of 2′-functionalized 3-aryltetrahydro and 3,4-dihydroisoquinolines

Several 2-functionalized 3-arylisoquinolines in different oxidation stages have been prepared. Fremy's salt or I2/NaAcO oxidation of 2-functionalized 3-aryltetrahydroisociuinolines always stops at the 3,4-dihydroisquinoline stage; however, bett

BENZOPHENANTHRIDES. XV. SYNTHESIS OF O-METHYLFAGARONINE IODIDE AND CHLORIDE FROM 13α-HYDROXYXYLOPININE

Hydroborination of 3-(2-vinyl-4,5-dimethoxyphenyl)-6,7-dimethoxy-2-methyl-1,2-dihydro-1-isoquinolone gave 3--6,7-dimethoxy-2-methylisoquinolin-1-one, which was converted by the action of various oxidizing agents into a benzophenanthridone derivative. 5-Methyl-5,6-dihydro-2,3,8,9-tetramethoxybenzophenanthridine, obtained from the above benzophenanthridone by reduction with LiAlH4 in tetrahydrofuran at 0 deg C, was converted into O-methylfagaronine iodide by boiling in an ethanolic solution of I2 in the presence of Na acetate.On exchanging I- by Cl-, O-methylfagaronine chloride was obtained in a quantitative yield in boiling methanol with an excess of AgCl.