136621-89-1

Basic information

• Product Name: N-<3-<(3-Hydroxymethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide
• Synonyms: N-<3-<(3-Hydroxymethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide
• CAS NO: 136621-89-1
• Molecular Weight: 365.456
• Mol File: 136621-89-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-<3-<(3-Hydroxymethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-<3-<(3-Hydroxymethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide(136621-89-1)
• EPA Substance Registry System: N-<3-<(3-Hydroxymethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide(136621-89-1)

Safety Data

• Hazardous Substances Data: 136621-89-1(Hazardous Substances Data)

Upstream product

• 139390-57-1 N-(3-Chloropropyl)-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide 
• 40599-33-5 3-(hydroxymethyl)phenol, sodium salt 

Downstream Products

• 136622-13-4 N-<3-<3-<(3-Hydroxy)pyrrolidinomethyl>phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide 
• 136622-12-3 N-<3-<3-(Pyrrolidinomethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide 
• 136622-15-6 N-[3-(3-{[(2-Hydroxy-ethyl)-methyl-amino]-methyl}-phenoxy)-propyl]-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-butyramide 
• 136622-14-5 N-[3-(3-Dimethylaminomethyl-phenoxy)-propyl]-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-butyramide 
• 136621-88-0 N-<3-<(3-Chloromethyl)phenoxy>propyl>-4-(1-methyl-1H-tetrazol-5-ylthio)butanamide 

Relevant articles and documents

Antiulcer agents. II. Synthesis and gastric acid antisecretory activity of N-[3-{3-(piperidinomethyl)phenoxy}propyl]-4-(1-methyl-1H-tetrazol-5- ylthio)butanamide and related compound

N-[3-{3-(Piperidinomethyl)phenoxy}propyl]butamides having a 1-methyl-1H-tetrazol-5-ylthio moiety as a pharmacophore and related compounds were prepared and tested for their antisecretory activity against histamine-induced gastric acid secretion in conscious rats with gastric fistulas. Most of the compounds showed antisecretory activity. Among them, N-[3-{3-(piperidinomethyl)phenoxy}propyl]-4-(1-methyl-1H-tetrazol-5- ylthio)butanamide (5f) was found to possess the most potent activity, and a possibility of isosteric replacement of the methoxycarbonyl group with 1-methyl-1H-tetrazol-5-yl group was indicated. The structure-activity relationships are also discussed.