136765-24-7 Usage
Description
ALPHA-HYDROXYALPRAZOLAM-D5, also known as α-hydroxyalprazolam, is a stable-labeled internal standard used for the quantitation of α-hydroxyalprazolam levels in biological samples such as urine, serum, or plasma. It plays a crucial role in various analytical techniques, including LC/MS or GC/MS, for applications like urine drug testing, clinical toxicology, forensic analysis, and isotope dilution methods. α-Hydroxyalprazolam is a major urinary metabolite of alprazolam, a benzodiazepine drug prescribed for treating panic and anxiety disorders.
Uses
Used in Urine Drug Testing:
ALPHA-HYDROXYALPRAZOLAM-D5 is used as an internal standard for the accurate quantitation of α-hydroxyalprazolam levels in urine samples. This application aids in the detection and monitoring of alprazolam usage, which is essential for assessing compliance with prescribed medications and identifying potential cases of drug abuse.
Used in Clinical Toxicology:
In the field of clinical toxicology, ALPHA-HYDROXYALPRAZOLAM-D5 serves as an internal standard to determine the concentration of α-hydroxyalprazolam in biological samples. This information is vital for diagnosing and managing cases of alprazolam overdose or intoxication, as well as understanding the potential interactions with other medications.
Used in Forensic Analysis:
ALPHA-HYDROXYALPRAZOLAM-D5 is utilized as an internal standard in forensic analysis to accurately measure α-hydroxyalprazolam levels in biological samples. This application is crucial for investigating cases involving alprazolam, such as drug-facilitated crimes or fatalities related to drug overdose.
Used in Isotope Dilution Methods:
In isotope dilution methods, ALPHA-HYDROXYALPRAZOLAM-D5 is employed as an internal standard to ensure the precision and accuracy of α-hydroxyalprazolam measurements. This technique is particularly useful in research and development, where accurate quantification of metabolites is essential for understanding the pharmacokinetics and pharmacodynamics of alprazolam.
Used in Pharmaceutical Research and Development:
ALPHA-HYDROXYALPRAZOLAM-D5 is used as a reference compound in the development of new drugs and therapies targeting anxiety disorders. By providing a stable and well-characterized standard, it enables researchers to accurately assess the efficacy and safety of new treatments in comparison to established medications like alprazolam.
Check Digit Verification of cas no
The CAS Registry Mumber 136765-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,7,6 and 5 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 136765-24:
(8*1)+(7*3)+(6*6)+(5*7)+(4*6)+(3*5)+(2*2)+(1*4)=147
147 % 10 = 7
So 136765-24-7 is a valid CAS Registry Number.
