1368500-40-6Relevant articles and documents
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties
Butini, Stefania,Gemma, Sandra,Brindisi, Margherita,Maramai, Samuele,Minetti, Patrizia,Celona, Diana,Napolitano, Raffaella,Borsini, Franco,Cabri, Walter,Fezza, Filomena,Merlini, Lucio,Dallavalle, Sabrina,Campiani, Giuseppe,MacCarrone, Mauro
, p. 492 - 495 (2013/02/25)
We herein describe the systematic approach used to develop new analogues of compound 2, recently identified as a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Aiming at identifying new scaffolds endowed with improved drug disposition properties with respect to the phenylpyrrole-based lead, we subjected it to two different structural modification strategies. This process allowed the identification of derivatives 4b and 5c as potent, reversible and non-competitive FAAH inhibitors.
